HIV阳性的海洛因依赖者戒毒前后120天CD4^＋T变化

目的：分析HIV阳性的海洛因依赖者戒毒前后（120天）CD4^＋T细胞的变化趋势，探讨戒毒对免疫功能的影响。方法：共有HIV阳性海洛因依赖者19例和同期HIV阴性海洛因依赖者25例入选本项研究。在入所7天内及戒毒120天后两次采集外周血，经流式细胞仪进行CD4^＋T细胞检测计数，SPSS11．5软件包统计分析。结果：HIV阳性与阴性者CD4^＋T细胞计数均值差异显著，HIV阳性的海洛因依赖者入所时CD4^＋T细胞计数值多数低于450×10^6／5，也有部分高于450×10^6／L.HIV阴性的海洛因依赖者CD4^＋T细胞计数均值戒毒后轻微下降。HIV阳性者CD4^＋T细胞计数均值戒毒后轻微上升，但两组间戒毒前后差值无统计学意义，组内CD4^＋T细胞计数戒毒前后无统计学差异。HIV阳性，且入所时CD4^＋T细胞值低于450×10^6／L的海洛因依赖者，戒毒120天后CD4^＋T细胞计数值显著上升，戒毒前后计数配对t检验，P〈0．01，差异高度显著。结论：海洛因依赖合并HIV感染且己表现免疫功能受损者戒毒有助于其CD4^＋T细胞回升，从而延缓艾滋病发病。

An analysis of difference of CD4+T cells of heroin addicts with HIV-positive before and after detoxitication

Objective： To analyze the trend of CD4^＋ T cells of heroin addicts with HIV-positive before and after detoxification （120 days）, and to assay drug effects on immune function. Methods： A total of 19 cases of HIV-positive heroin abusers and 25 cases HIV-negative heroin abusers were selected in study. Fasting peripheral venous blood 2 mL was collected at the beginning of detoxification and 120 d of detoxifying. CD4^＋ T cell werecounted detected by flow cytometry. Statistical difference was analysis by SPSS software package between the two groups and before and after detoxification. Results： There were significant differences of CD4Aa^＋ T cell count between HIV-positive heroin addicts and HIV-negative heroin abusers before and after treatment. Majority count of HIV-positive less than 450 × 10^6/L, but a small part of HIV-positive addicts highter than 450 × 10^6/L. The mean of CD4^＋ T cell count of HIV negative heroin abusers decreased slight, and the mean count of HIV positive increased slight after detoxification for 120 days, but the algebraic difference of the CD4^＋ T-cell count from the beginning to the 120 d of detoxifying between the two groups was no statistical significance. The CD4^＋ T cell count at the beginning and 120 d of detoxifying were no significant differences also for each group. But in the HIV-positive group, for the part of CD4^＋ T cell count less than 450 × 10^6/L at beginning, the count increased significantly （P〈0. 001）. Conclusions： Detoxifying is helpful for the heroin addicts combination with HIV infection and displayed immune function damage detoxifying to recovery the count ofCD4^＋ T cell, and delayed the aids onset.