| 哌甲酯对注意缺陷多动障碍患儿事件相关电位的影响 |
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| 引用本文： | 郭蕴岚,郭蕴琦,王家勤,寇根生,高志涛,宁夔,张志亮,王业民,邓智建,段敬利,杨庆南. 哌甲酯对注意缺陷多动障碍患儿事件相关电位的影响[J]. 实用儿科临床杂志, 2011, 0(3): 204-205,211 |
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| 作者姓名： | 郭蕴岚 郭蕴琦 王家勤 寇根生 高志涛 宁夔 张志亮 王业民 邓智建 段敬利 杨庆南 |
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| 作者单位： | 新乡医学院第三附属医院药剂科;新乡医学院第一附属医院药剂科;新乡医学院第三附属医院儿科;新乡医学院第二附属医院精神科;新乡医学院第二附属医院电生理室 |
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| 摘 要： | 目的比较哌甲酯对注意缺陷多动障碍(ADHD)患儿治疗前后事件相关电位的影响。方法 ADHD患儿32例口服哌甲酯后应用丹迪Keypoint肌电-诱发电位仪进行Go/Nogo任务的事件相关电位检测,以30名健康儿童作为健康对照组,对事件相关电位主成分进行比较。应用SPSS 13.0软件进行统计学分析。结果 ADHD患儿服药后Go-P3潜伏期(355.16±17.04)ms,短于服药前(366.66±19.32)ms,但长于健康对照组(333.70±23.57)ms(Pa<0.05);波幅(5.88±1.72)μV,高于服药前(4.82±2.14)μV,但低于健康对照组(7.19±1.87)μV(Pa<0.05);ADHD患儿服药后Nogo-P3波幅(6.13±1.68)μV,高于服药前(5.04±1.76)μV,但低于健康对照组(8.32±2.03)μV(P<0.05,0.01)。结论哌甲酯能改善ADHD患儿的注意性及抑制性执行功能。
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| 关 键 词： | 注意缺陷多动障碍 哌甲酯 事件相关电位 执行功能 儿童 |
Effects of Methylphenidate on Event Related Potential in Children with Attention Deficit Hyperactivity Disorder |
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| GUO Yun-lan,GUO Yun-qi,WANG Jia-qin,KOU Gen-sheng,GAO Zhi-tao,NING Kui,ZHANG Zhi-liang,WANG Ye-min,DENG Zhi-jian,DUAN Jing-li,YANG Qing-nan. Effects of Methylphenidate on Event Related Potential in Children with Attention Deficit Hyperactivity Disorder[J]. Journal of Applied Clinical Pediatrics, 2011, 0(3): 204-205,211 |
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| Authors: | GUO Yun-lan GUO Yun-qi WANG Jia-qin KOU Gen-sheng GAO Zhi-tao NING Kui ZHANG Zhi-liang WANG Ye-min DENG Zhi-jian DUAN Jing-li YANG Qing-nan |
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| Affiliation: | 1.Pharmaceutical Preparation Section,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;2.Pharmaceutical Preparation Section,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China;3.Department of Pediatrics,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;4.Department of Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China;5.Department of Electrophysiology,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China) |
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| Abstract: | Objective To investigate the effect of methylphenidate on event related potential(ERP) in children with attention deficit hyperactivity disorder(ADHD).Methods Thirty-two children with ADHD(ADHD group)were treated for oral using methylphenidate and observed for 2 hours,scale for the assessment of methylphenidate were evaluated with the P300 ERP in Go/Nogo task.Thirty healthy children(healthy control group) were controls,to compare the differences of ERP main components.Results The latency[(355.16±17.04) ms] and amplitude[(5.88±1.72) μV] of Go-P3 in ADHD group after treatment were significantly shorter and higher than before treatment[(366.66±19.32) ms and(4.82±2.14) μV,Pa<0.05],but longer and lower than those in healthy control group[(333.70±23.57) ms and(7.19±1.87) μV,Pa<0.05].The amplitude [(6.13±1.68) μV] of Nogo-P3 in ADHD group after treatment were significantly higher than before treatment[(5.04±1.76) μV,P<0.05],but lower than that in healthy control group[(8.32±2.03) μV,P<0.05].Conclusion Methylphenidate can improve the attention and inhibitive executive functions in children with ADHD. |
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| Keywords: | attention deficit hyperactivity disorder methylphenidate event related potential executive function child |
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