The inter-relationship of factor VII and its activity state with plasma lipids in healthy male adults |
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| Authors: | D. Wright,,L. Poller,J. M. Thomson,,E. Gowland,G. E. Burrows,&dagger |
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| Affiliation: | UK Reference Laboratory for Anticoagulant Reagents and Control, Withington Hospital, Manchester;Department of Chemical Pathology, Universitg of South Manchester;Department of Occupational Health and Safety, University of Manchester |
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| Abstract: | Summary A close inter-relationship between raised factor VII clotting activity and elevated blood lipids, particularly serum triglycerides, is well established. A study of factor VII, its activation state and of plasma lipids has been undertaken in two groups of healthy middle-aged males to elucidate this mechanism. A control group with normal factor VII levels were closely matched for age and body-mass index with a second group with elevated levels. Factor VII assays, using rabbit and bovine thromboplastin and a factor VII Ag method, were employed. Triglycerides correlated with the rabbit factor VII thromboplastin assay and factor VII Ag ( P <0.05) but not with the bovine thromboplastin method. Higher HDL-cholesterol and apolipoprotein A-I levels were found in subjects with increased factor VII ( P <0.001) and appeared to be due to differences in alcohol consumption. Cholesterol levels were significantly higher with elevated factor VII. Differential testing suggests that higher factor VII is predominantly mediated through a rise in total VII, rather than an increase in its activity state. |
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