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| Evaluation of urine ELISA test for detecting Helicobacter pylori infection in Taiwan： A prospective study | |
| 作者姓名： | Kuo FC Wang SW Wu IC Yu FJ Yang YC Wu JY Wang WM Wu DC |
| 作者单位： | Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Taiwan China,Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Taiwan China,Department of Clinical Pathology Kaohsiung Medical University Hospital Taiwan China,Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Taiwan China,Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Taiwan China |
| 基金项目： | Supported by the grants from the National Science Council of the Taiwan, No. NSC91-2315-B-037-003 |
| 摘 要： | AIM: To evaluate the diagnostic accuracy and clinical utility of a new ELISA (URINELISA) test for detecting Helicobacter pylori(H pylori) antibody in the urine of Taiwanese population. METHODS: In this prospective study, 317 consecutive dyspeptic patients (171 men, 146 women; mean age, 51.0 years) were included. They underwent gastroendoscopy for evaluation. Invasive tests, including culture, histology, and rapid urease test (RUT), and non-invasive ~(13)C-urea breath test were preformed. At the same time, urine specimens were collected for URINELISA. The status of H pylori infection was considered as positive when either culture was positive, or when two of the other, RUT, histology or 13C-UBT, were positive. RESULTS: The sensitivity, specificity, positive predictive value, and negative predictive value of URINELISA are 91.7% (211/230), 90.8% (79/87), 96.3% (211/219), and 80.6% (79/98) respectively. CONCLUSION: This URINELISA test is reliable, inexpensive and easy-to-use. The high diagnostic accuracy warrants the use of URINELISA as a first-line screening tool for diagnosis of H pylori infection in untreated patients. |
| 关 键 词： | 尿液检查 疾病传染 台湾省 中国 幽门螺杆菌 消化系统 |
| 收稿时间： | 2004 Dec 14 |
Evaluation of urine ELISA test for detecting Helicobacter pylori infection in Taiwan: a prospective study |
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| Kuo FC,Wang SW,Wu IC,Yu FJ,Yang YC,Wu JY,Wang WM,Wu DC.Evaluation of urine ELISA test for detecting Helicobacter pylori infection in Taiwan: a prospective study[J].World Journal of Gastroenterology,2005,11(35):5545-5548. | |
| Authors: | Kuo Fu-Chen Wang Sheng-Wen Wu I-Chen Yu Fang-Jung Yang Yuan-Chieh Wu Jeng-Yih Wang Wen-Ming Wu Deng-Chyang |
| Institution: | 1. Department of Gynecology and Obstetrics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan, China 2. Division of Gastroenterology,Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan, China 3. Department of Clinical Pathology, Kaohsiung Medical University Hospital, Taiwan, China |
| Abstract: | AIM: To evaluate the diagnostic accuracy and clinical utility of a new ELISA (URINELISA) test for detecting Helicobacter pylori(H pylori) antibody in the urine of Taiwanese population. METHODS: In this prospective study, 317 consecutive dyspeptic patients (171 men, 146 women; mean age, 51.0 years) were included. They underwent gastroendoscopy for evaluation. Invasive tests, including culture, histology, and rapid urease test (RUT), and non-invasive ~(13)C-urea breath test were preformed. At the same time, urine specimens were collected for URINELISA. The status of H pylori infection was considered as positive when either culture was positive, or when two of the other, RUT, histology or 13C-UBT, were positive. RESULTS: The sensitivity, specificity, positive predictive value, and negative predictive value of URINELISA are 91.7% (211/230), 90.8% (79/87), 96.3% (211/219), and 80.6% (79/98) respectively. CONCLUSION: This URINELISA test is reliable, inexpensive and easy-to-use. The high diagnostic accuracy warrants the use of URINELISA as a first-line screening tool for diagnosis of H pylori infection in untreated patients. |
| Keywords: | Hpylori URINELISA |
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