| 10周金硫葡萄糖致肥小鼠棕色脂肪组织乙酰辅酶A羧化酶的活性 |
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| 引用本文： | 陈文缘,G.J.Cooneg,G.S Denyer,P.F.Williams,I.D.Catersin.10周金硫葡萄糖致肥小鼠棕色脂肪组织乙酰辅酶A羧化酶的活性[J].泸州医学院学报,1991(3). |
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| 作者姓名： | 陈文缘 G.J.Cooneg G.S Denyer P.F.Williams I.D.Catersin |
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| 作者单位： | 泸州医学院生化教研室，澳大利亚悉尼大学内分泌系，澳大利亚悉尼大学内分泌系，澳大利亚悉尼大学内分泌系，澳大利亚悉尼大学内分泌系 |
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| 摘 要： | 本文对10周肥胖小鼠的血糖、血胰岛素浓度和棕色脂肪组织的乙酰辅酶A羧化酶(ACC)活性进行了研究.10周金硫葡萄糖(GTG)小鼠呈现高血糖,高胰岛素血症,其棕色脂肪组织用u/g鲜组织表示的ACC活性均低于对照,而用mu/mg蛋白质表示时,三组动物的总ACC活性与对照无明显差异.基础和柠檬酸盐刺激的ACC活性则低于对照.结果表明,10周GTG肥胖鼠棕色脂肪组织存在胰岛素抵抗.
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| 关 键 词： | GTG肥胖鼠 棕色脂肪组织 乙酰辅酶A羧化酶 胰岛素抵抗 |
ACETYL-CoA CARBOXYLASE ACTIVITY IN BROWN ADIPOSE TISSUE OF 10 WEEK-GOLD THIOGLUCOSE-OBESE MICE |
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| Chen Wenyuan.ACETYL-CoA CARBOXYLASE ACTIVITY IN BROWN ADIPOSE TISSUE OF 10 WEEK-GOLD THIOGLUCOSE-OBESE MICE[J].Journal of Luzhou Medical College,1991(3). |
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| Authors: | Chen Wenyuan |
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| Institution: | Chen Wenyuan Department of Biochemistry |
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| Abstract: | The plasma glucose and insulin concentrations and activity of ACC in the brown adipose tissue (BAT) were studied on 10 week-gold thioglucose(GTG)-obese mice in this article. The GTG obese mice were hyperglycaenic and hyperinsulinaemic. The activity of ACC (u/g fresh tissue) in the BAT of all the GTG mice was reduced. The basal and citrate-stimulated activities of ACC (mu/mg protein) were also reduced but the entire activity of ACC (mu/mg protein) was not significantly diffrent from that of the control mice. The results indicated that the insulin resistance was present in the BAT of 10 week-GTG mice. |
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| Keywords: | GTG-obese mice Brown adipose tissue Acetyl-coA carboxylase Insulin resistance |
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