药物超敏反应综合征发病机制及治疗的研究进展

药物超敏反应综合征是一种具有特异征候的重症药疹。目前认为,在一定的遗传背景下,机体对药物活性代谢产物解毒功能的缺陷是其病因之一,人疱疹病毒-6感染再激活也参与了此病的发生。药物及病毒再激活引发的免疫过敏反应所致组织损害主要南CD8 细胞毒性T淋巴细胞造成。针对其病理生理改变,最有效的治疗是采用激素与免疫球蛋白联合疗法。

Drug-induced Hypersensitivity Syndrome

Drug-induced hypersensitivity syndrome (DIHS) is a severe drug eruption with characteristic symptoms. The etiology of DIHS is complex and the mechanism of it has not been fully elucidated. The pathogenic factors include the defect in the process of detoxifying reactive drug metabolites, which is related to a specific genetic background, and human herpes virus 6 (HHV-6) reactivation. The drug and virus reactivation destroy tissues by an immune allergic reaction. And the destruction is primarily caused by CD8 cytotoxic T lymphocytes. Aiming at the pathological changes, systemic glucocorticoids (GS) with intravenous immunoglobulin (IVIG) are the most effective therapy.