内皮素、一氧化氮在毛细支气管炎和哮喘患儿中的变化

目的　 探讨血内皮素 (ET)和一氧化氮 (NO)在毛细支气管炎 (毛支 )和婴幼儿哮喘 (哮喘 )中的变化及意义。 方法 　用放射免疫分析法和分光光度比色法分别检测毛支、哮喘患儿急性期和缓解期血ET和NO ,并与正常儿童进行比较。 结果 　血浆ET在毛支组和哮喘组 ,急性期均明显高于正常组 (P均 <0 0 1) ,缓解期均下降 ,与正常组比较无显著差别 (P均 >0 0 5 ) ;两组急性期比较无差别 (P >0 0 5 )。与血浆ET一样 ,血清NO在毛支组和哮喘组 ,急性期均显著高于正常组 (P <0 0 1和P <0 0 5 ) ;缓解期则下降 ,与对照组比无显著差别 ,(P均 >0 0 5 ) ;两组急性期相比 ,差异无显著性 (P >0 0 5 )。两组急性期血浆ET与血清NO呈明显正相关 (P <0 0 5 )。 结论 　在毛支和哮喘中 ,血ET和NO均升高 ,二者关系密切 ,均可能参与毛支及哮喘的发病

Change on plasma endothelin and serum nitric oxide in infant with bronchiolitis and asthma

Objective To study the change and significance of plasma endothelin(P ET) and serum nitric oxide (S NO) in infants with bronchiolitis and asthma.Methods The P ET and S NO of children with bronchiolitis were determined by radioimmunoassay and colorimetry respectively and compared with normal children.Results The P ETs of infants with bronchiolitis and asthma were significantly higher compared with that in normal group in acute period,respectively (all of P <0^01),and all decreased and was no difference Compared with normal group in remission period (all of P >0^05).The P ET in acute period was different in bronchiolitis group and asthma group ( P >0^05).The S NOs of two group were same changes as their P ET. The P ET of two groups was significantly positively related to their S NO in acute period (r=0^164, P <0^05).Conclusion This study showed that the P ET and S NO were all elevated in bronchiolitis and asthma and both had a mutual attraction.ET and NO may play an important role in the pathogenesis of bronchiolitis and infant asthma.