Peripheral CD4+ CD8- γδ T cell lymphoma: A case report with multiparameter analyses |
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| Authors: | Ryo Ichinohasama MD PhD Ikuo Miura MD PhD Tohru Takahashi MD PhD Yuji Yaginuma MD PhD Jerome Myers MD PhD John F Decoteau MD Charles Yee MD Marshall E Kadin MD Shigeo Mori MD PhD Takashi Sawai MD PhD |
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| Affiliation: | aDepartment of Pathology, Tohoku University Hospital, Third Department of Internal Medicine, Akita University School of Medicine, Tokyo, Japan;bDepartment of Internal Medicine and Otorhinolaryngology, Hiraka General Hospital, Tokyo, Japan;cDepartment of Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan;dDepartment of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, MA USA |
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| Abstract: | A 72-year-old Japanese man presented with CD4+ T cell receptor (TCR) γδ T cell lymphoma involving bilateral cervical lymph nodes. No involvement by tumor was observed in the liver, spleen, nasal cavity, or bone marrow throughout his clinical course. Although the tumor adequately responded to chemotherapy and irradiation, he relapsed with short remission and a slowly aggressive clinical course, and died 24 months after onset. Simultaneous expression of TCRγδ with other T-cell antigens on the lymphoma cells was analyzed by 3-color flow cytometry (3-FCM), and showed a unique phenotype CD3+ CD4+ CD8− CD7− CD5+ CD2++ TCRαβ (WT31)- βF1-TCRγδ1 (11F2)+ TCRδ1+. Cytogenetic analysis showed 79–81 and structural abnormalities consisting of del(1) (p11) and i(17)(q10). But no abnormality was identified in chromosome 7. DNA analysis revealed gene rearrangements of TCRγ and δ, while a nongerm line band in TCRβ was aberrantly seen. These observations suggest a new subtype of γδ T-cell lymphoma, which is characterized by CD4 positivity and by a clinical course not as aggressive as other predominant subtypes. |
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| Keywords: | peripheral T cell lymphoma CD4+ CD8- γδ T cell three-color flow cytometry |
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