| 应用人工神经网络研究红霉素缓释微囊的体内外相关性 |
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| 引用本文： | 李凌冰,李琇. 应用人工神经网络研究红霉素缓释微囊的体内外相关性[J]. 中国医药工业杂志, 2003, 34(12): 610-612 |
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| 作者姓名： | 李凌冰 李琇 |
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| 作者单位： | 1. 山东大学药学院药剂教研室
2. 山东大学校医院,山东济南,250012 |
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| 基金项目： | 山东大学跨学科预研基金 (2 13 10 0 5 13 10 0 81) |
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| 摘 要： | 以明胶为囊材制备了红霉素缓释微囊，并采用人工神经网络对微囊的体内外相关性进行研究。以体外释放度的数据作为输入、血药浓度数据作为输出训练神经网络系统，通过比较体内血药浓度实测值与预测值的差异考察网络的可靠性，结果表明本网络得到的体内外相关性较好。
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| 关 键 词： | 红霉素缓释微囊 人工神经网络 体内外相关性 |
| 文章编号： | 1001-8255(2003)12-0610-03 |
| 修稿时间： | 2002-11-13 |
In vivo-in vitro Correlation for Erythromycin Sustained Release Microcapsules Using Artificial Neural Network |
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| LI Ling Bing ,LI Xiu. In vivo-in vitro Correlation for Erythromycin Sustained Release Microcapsules Using Artificial Neural Network[J]. , 2003, 34(12): 610-612 |
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| Authors: | LI Ling Bing LI Xiu |
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| Affiliation: | LI Ling Bing 1,LI Xiu 2 |
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| Abstract: | Sustained release gelatin microcapsules of erythromycin were prepared and in vivo in vitro correlation was investigated using artificial neural network (ANN). In vitro data and in vivo data were used as the ANN model input and output, respectively. Internal predictability was assessed by comparing observed and predicted values for in vivo data. The results showed that ANN had satisfactory in vivo in vitro correlation. |
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| Keywords: | erythromycin sustained release microcapsules artificial neural network in vivo in vitro correlation |
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