Intramyocardial Influences on Blood Flow Distributions in the Myocardial Wall |
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Authors: | Fumihiko Kajiya Toyotaka Yada Takeshi Matsumoto Masami Goto Yasuo Ogasawara |
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Affiliation: | (1) Department of Medical Engineering and Systems Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan |
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Abstract: | Flow velocity wave forms of coronary arterial inflow and venous outflow of myocardium are influenced by cardiac contraction and relaxation: arterial flow is exclusively diastolic; venous outflow is systolic. We first discuss the intramyocardial microvascular flow dynamics, then present some results of visualization of transmural microvessels by our needle-probe charge coupled device (CCD) microscope, along with an interpretation of the arteriolar and venular hemodynamics through a cardiac cycle. After describing a hierarchical system of coronary microvessels (small artery, arteriole, and capillary), we emphasize the importance of spatial heterogeneity of blood supply to myocardium with reference to a minimal vascular control unit (400 m). An understanding of mechanoenergetic interaction is fundamentally important to an understanding of intramyocardial coronary circulation, and the Physiome Project will provide powerful tools for understanding the integrated role of the intramyocardial microcirculation system. © 2000 Biomedical Engineering Society.PAC00: 8719Hh, 8719Ff, 8719Tt |
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Keywords: | Intramyocardial coronary microcirculation Needle-probe charge coupled device (CCD) microscope Microregulatory unit of flow Flow heterogeneity |
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