| 齐墩果酸/PLGA-TPGS纳米粒的制备及其体外释放行为研究 |
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| 引用本文： | 顾晓华,王轩,安磊,蒋妮,高萌,梅林,田燕.齐墩果酸/PLGA-TPGS纳米粒的制备及其体外释放行为研究[J].中国药房,2012(29):2726-2728. |
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| 作者姓名： | 顾晓华 王轩 安磊 蒋妮 高萌 梅林 田燕 |
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| 作者单位： | [1]大连医科大学附属第一医院药剂科,辽宁大连116011 [2]大连医科大学,辽宁大连116044 [3]大连儿童医院药剂科,辽宁大连116001 |
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| 基金项目： | 辽宁省教育厅2010年度资助课题（L2010129） |
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| 摘 要： | 目的:制备齐墩果酸/乳酸羟基乙酸共聚物-水溶性维生素E衍生物(PLGA-TPGS)纳米粒(OPN)并考察其体外释放情况。方法:用自制的PLGA-TPGS为载体材料,采用超声乳化-溶剂挥发法制备OPN,考察其粒径、Zeta电位、载药量、包封率、体外累积释放率。结果:所制OPN的平均粒径为(202.4±1.2)nm,Zeta电位为(-21.5±2.2)mV,载药量为(27.65±2.27)%,包封率为(92.52±2.15)%,其在含1.0%十二烷基硫酸钠的磷酸盐缓冲液(pH7.4)中呈两相释放,432h时累积释放率为(93.8±2.9)%。结论:所制OPN质量稳定、可控,具有明显的体外缓释作用。
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| 关 键 词： | 齐墩果酸 乳酸羟基乙酸共聚物-水溶性维生素E 纳米粒 高效液相色谱法 体外释放 |
Preparation and in Vitro Release Study of Oleanolic Aeid/PLGA-TPGS Nanoparticles |
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| GU Xiao-hua,WANG Xuan,AN Lei,GAO Meng,MEI Lin,TIAN Yan.Preparation and in Vitro Release Study of Oleanolic Aeid/PLGA-TPGS Nanoparticles[J].China Pharmacy,2012(29):2726-2728. |
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| Authors: | GU Xiao-hua WANG Xuan AN Lei GAO Meng MEI Lin TIAN Yan |
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| Institution: | ,JIANG Ni(Dept. of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Liaoning Dalian 116011, China;Dalian Medical University, Liaoning Dalian 116044, China;Dept. of Pharmacy, Dalian Children Hospital, Liaoning Dalian 116001, China) |
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| Abstract: | OBJECTIVE： To prepare Oleanolic acid/polylactic-co-glycolic acid-D-a-tocopherol polyethylene glycol succinate de-rivates （PLGA-TPGS） nanoparticles （OPN） and to determine its in vitro release rate. METHODS： OPN were prepared by ultrasoni-cation emulsion-solvent evaporation technique using PLGA-TPGS as carrier. Its panicle size, Zeta potential, drug-loading and en- capsulation efficiency and in vitro release rate were determined. RESULTS： The OPN was sphere-like with mean particle size of （202.4 ±1.2） nm, Zeta potential of （ -21.5 ± 2.2） mV, drug-loading amount of （27.65 ±2.27）% and encapsulation efficiency of （92.52 ± 2,15）%. The in vitro drug release profile in phosphate buffer solution of pH 7.4 containing 1.0% sodium dodecyl sulfate showed diphasic release pattern, and the accumulative release rate was （93.8 ±2.9）% at 432 h. CONCLUSION： The OPN is stable and controllable in quality, and shows obvious sustained-release in vitro. |
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| Keywords: | Oleanolic acid PLGA-TPGS Nanoparticles HPLC In vitro release |
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