自拟方剂配合放疗治疗中晚期食管癌的疗效观察

目的:观察自拟方剂配合放疗治疗中晚期食管癌的疗效。方法:156例中晚期食管癌患者随机分为对照组和治疗组各78例,2组均采用常规三野照射,接受6mV-X射线直线加速器照射,每次200cGy,每周5次,3周为1个疗程,连续2个疗程;治疗组在接受放射治疗的同时加服自拟方剂,每天1剂,3周为1个疗程,连续2个疗程。统计总有效率与不良反应。结果:治疗后,对照组患者完全缓解6例,部分缓解53例,无缓解19例,总有效率75.64%;治疗组患者完全缓解7例,部分缓解61例,无缓解10例,总有效率87.18%;2组总有效率比较有显著性差异(P<0.05)。对照组患者放疗后出现骨髓抑制45例,放射性食管炎22例,放射性气管炎26例,胃肠道反应15例;治疗组患者放疗后出现骨髓抑制21例,放射性食管炎15例,放射性气管炎19例,胃肠道反应8例;2组毒副作用比较有显著性差异(P<0.05)。结论:采用自拟方剂配合放疗治疗中晚期食管癌患者可显著提高疗效,降低放射治疗引起的毒副作用,改善患者的机体免疫力和全身状况。

Efficacy Observation of TCM Combined with Radiotherapy for Moderate or Advanced Esophageal Cancer

OBJECTIVE： To observe therapeutic efficacy of TCM combined with radiotherapy for moderate or advanced esophageal cancer. METHODS： 156 cases of moderate or advanced esophageal cancer patients were randomly divided into control group and treatment group with 78 cases in each group. 2 groups were given conventional three-field irradiation using 6 mV-X ray linear accelerator 200 cGy every time, 5 times a week, 3 weeks for a courses; in treatment group patients received radiation therapy and TCM decoction, 1 doses per day, 3 week for a course of treatment, for continuous 2 Courses. Total effective rate and ADR were censused. RESULTS： After treatment, control group had 6 cases of complete remission, 53 cases of partial remission, 19 cases of no remission, total effective rate was 75.64% ; treatment group 7 cases of complete remission, 61 cases of partial remission, 10 cases of no remission, the total effective rate was 87.18%; the total effective rate of 2 groups had significant difference（P〈0.05）. 45 patients suffered from bone marrow depression in control group after radiotherapy, 22 cases of radiation esophagitis, 26 cases of radiation bronchitis, 15 cases of gastrointestinal reactions; 21 patients suffered from bone marrow depression in treatment group after radiotherapy, 15 cases of radiation esophagitis, 19 cases of radiation bronchitis, 8 cases of gastrointestinal reactions; toxic side effect of 2 groups had significant difference （P〈0.05）. CONCLUSION： TCM decoction combined with radiotherapy in the treatment of moderate or advanced esophageal cancer can improve the curative efficacy, reduce radiation-induced toxic side effects and improve patients＇ immunity and systemic conditions.