奥美拉唑联合法莫替丁与单用雷尼替丁治疗消化性溃疡的疗效比较

目的:比较奥美拉唑联合法莫替丁与单用雷尼替丁治疗消化性溃疡的疗效。方法:将我院2009年1月-2010年11月住院的消化性溃疡患者95例随机分为联合治疗组(48例,应用奥美拉唑联合法莫替丁治疗)与雷尼替丁组(47例,单用雷尼替丁治疗),2组均应用左氧氟沙星进行抗菌治疗。2组均随访6个月,观察并比较治疗后2组胃内pH值、幽门螺旋杆菌(Hp)是否根除等指标。结果:与雷尼替丁组比较,联合治疗组抗酸能力强而持久(P<0.05)。经过6个月的随访,联合治疗组Hp清除更彻底(P<0.05)。2组均未见严重不良反应发生。结论:奥美拉唑联合法莫替丁治疗消化道溃疡疗效确切、安全性较好。

Comparison of Therapeutic Efficacy of Omeprazole Combined with Famotidine vs.Ranitidine in the Treatment of Peptic Ulcer

OBJECTIVE:To observe therapeutic efficacy of omeprazole combined with famotidine vs.ranitidine in the treatment of peptic ulcer.METHODS:From Jan.2009 to Nov.2010,95 inpatients with peptic ulcer were randomly divided into combined therapy group(48 cases,omeprazole combined with famotidine) and ranitidine group(47 cases,ranitidine).Levofloxacin was used to make antibiotic treatment in 2 groups.All cases were followed up for 6 months.pH in stomach,helicobacter pylori(Hp) eradicated or not and other indicators were compared before and after treatment.RESULTS:After 4 weeks treatment,peptic ulcer symptoms of 2 groups were improved.Compared with ranitidine group,acid resistance capacity of combined therapy group was strong and persistent(P<0.05).After 6 months following-up,Hp was removed completely in combined therapy group(P<0.05).No severe ADR was found in 2 groups.CONCLUSION:Omeprazole combined with famotidine is effective and safe in treatment of peptic ulcer.