调节性T细胞及相关细胞因子与同种小肠移植耐受

许多对于宿主免疫耐受中调节性T细胞作用的研究提供了大量有意义的结果。在小肠移植，抗CD4mAb和抗CD8mAbs均抑制排斥，但抗CD4mAb更有效；CD4^ CD25^T细胞的免疫抑制性表现在经TCR介导信号刺激活化以后能够抑制CD4^ 和CD8^ T细胞的活化和增殖，从而抑制排斥反应的发生实现耐受；调节性T细胞分泌的关键细胞因子与小肠移植排斥反应的发生、发展密切相关。通过少量关键的相关细胞因子改变免疫反应，成为实现同种小肠移植耐受的具有高度可行性的重要方法。

Regulatory T cells and its related cytokines in small bowel transplantation tolerance

The research of effect of regulatory T cell on host immu no logical tolerance shows many significant results. In small bowel transplantation , both anti CD4 mAb and anti CD8mAb suppress allograft rejection, but anti CD 4mAb is more effective; The suppressor function of CD4 +CD25 + T cell which th rough TCR trans signal activation result in suppressor activation and prolifer ation of CD4 + and CD8 + T cells, suppressor rejection and leads to tolerance. T he key cytokines secreted by regulatory T cell is closely related to occurrence and development of rejection in small bowel transplantation. It is an important feasible method to get allograft tolerance in small bowel transplantation by ch anging the immunologic reaction with key cytokines.