THE EFFECT OF THE ''HYPERTENSINOGENIC STEROID, 9α-FLUORO-CORTISOL ON BLOOD PRESSURE IN SHEEP WITH ACTH-INDUCED HYPERTENSION |
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| Authors: | Eric H. Mills John P. Coghlan Derek A. Denton Mark A. Nelson Campbell D. Spence Judith A. Whitworth Bruce A. Scoggins |
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| Affiliation: | Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne;*Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia |
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| Abstract: | The effect of treatment with 9 alpha-fluorocortisol (9 alpha FF), a steroid which causes hypertension in sheep, was examined in sheep with ACTH-induced hypertension. ACTH treatment alone increased mean arterial pressure (MAP), plasma Na concentration, water intake and urine volume and decreased plasma K concentration. 9 alpha FF treatment, for 3 days during continuing ACTH administration, did not change blood pressure but increased heart rate, water intake and urine volume and decreased urinary K excretion. As 9 alpha FF did not cause a further increment in blood pressure in sheep with ACTH-induced hypertension it is possible that both ACTH and 9 alpha FF may produce hypertension by similar mechanisms. |
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| Keywords: | ACTH, 9α-fluorocortisol, hypertension, potassium, sheep, sodium. |
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