气腹影响肝脏吲哚青绿排泄的实验研究

目的 腹腔镜手术中气腹对机体生理功能的一些影响是已知的。本研究以吲哚青绿（ICG）药代动力学参数作为肝脏血流指数，观察气腹时的变化情况。方法 雄性Wistar大鼠18只，随机分面三组：麻醉组、开腹组、气腹组。气腹压力为8mmHg，ICG（1mg/kg0股静脉给药，进行ICG15min排泄试验。结果 分别测得各组血清ICG含量，开腹组ICG水平虽高于麻醉组，但无统计学差异（P＞0.05）。而所腹组ICG水平显著高于麻醉组及开腹组（P＜0.05）。结论 所腹使ICG排泄降低的结果，证实了腹腔镜手术中气腹压力可减少肝脏血流量。

Effects of pneumoperitoneum on hepatic indocyanine green clearance in rats

Objective To determine if indocyanine green(ICG)pharmacokinetic parameters,as indices of hepatic blood flow,change during abdominal insufltation.Methods Eighteen male Wistar rats were randomized into 3 groups to receive anesthesia,laparotomy and pneumoperitoneum,respectively.Pneumoperitoneum was per- formed at 8 mmHg.ICG(1mg/kg)was injected into a fermoral vein.ICG clearance test was conducted in all the 3 groups.Results The ICG level was slightly higher in laparotomy group than in anesthesia group(P>0.05). However,the level was significantly higher in pneumoperitoneum group than in the former 2 groups(P<0.05). Conclusions Pneumoperitoneum can be used to decrease liver blood flow during laparoscopic surgery.