Dopamine transporter imaging with [123I]FP-CIT SPECT: potential effects of drugs |
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Authors: | Jan Booij Paul Kemp |
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Institution: | (1) Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands;(2) Department of Nuclear Medicine, Southampton University Hospitals Trust, Southampton, UK |
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Abstract: | Background 123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-{4-iodophenyl}nortropane (123I]FP-CIT) single photon emission computed tomography (SPECT) is a frequently and routinely used technique to detect or exclude
dopaminergic degeneration by imaging the dopamine transporter (DAT) in parkinsonian and demented patients. This technique
is also used in scientific studies in humans, as well as in preclinical studies to assess the availability of DAT binding
in the striatum. In routine clinical studies, but also in scientific studies, patients are frequently on medication and sometimes
even use drugs of abuse. Moreover, in preclinical studies, animals will be anesthetized. Prescribed drugs, drugs of abuse,
and anesthetics may influence the visual interpretation and/or quantification of 123I]FP-CIT SPECT scans.
Discussion Here, we discuss the basic principle of how drugs and anesthetics might influence the visual interpretation and/or quantification
of 123I]FP-CIT SPECT scans. We also review drugs which are likely to have a significant influence on the visual interpretation and/or
quantification of 123I]FP-CIT SPECT scans. Additionally, we discuss the evidence as to whether frequently prescribed drugs in parkinsonian and
demented patients may have an influence on the visual interpretation and/or quantification of 123I]FP-CIT SPECT scans. Finally, we discuss our recommendations as to which drugs should be ideally withdrawn before performing
a 123I]FP-CIT SPECT scan for routine clinical purposes. The decision to withdraw any medication must always be made by the specialist
in charge of the patient’s care and taking into account the pros and cons of doing so. |
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Keywords: | [123I]FP-CIT SPECT Dopamine transporter Drugs Withdrawal Effects |
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