Long-term survival in children under 3 years of age with low-grade astrocytoma |
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| Authors: | Roberto Rivera-Luna Marta Zapata-Tarrés Aurora Medina-Sansón Enrique López-Aguilar Ana Niembro-Zúñiga J. Amador Zarco Alfonso Marhx-Bracho Fernando Rueda-Franco Leticia Bornstein-Quevedo |
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| Affiliation: | (1) Division of Hem/Oncology and Radiotherapy, National Institute of Pediatrics [Instituto Nacional de Pediatría], Insurgentes Sur no. 3700-C, Mexico City, D F, 04530, México;(2) Department of Oncology, Hospital Infantil de México, Mexico City, México;(3) Department of Oncology, Hospital de Pediatría, CMN Siglo XXI, IMSS, Mexico City, México;(4) Neurosurgery Department, National Institute of Pediatrics, Mexico City, México;(5) Division of Neurosciences, National Institute of Pediatrics, Mexico City, México;(6) Department of Pathology, National Institute of Pediatrics, Mexico City, México;(7) Mexican Cooperative Group for Childhood Malignancies, Mexico City, México;(8) Childhood Committee for Hem/Oncology Diseases, National Academy of Medicine [Academia Nacional de Medicina de México], Mexico City, México |
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| Abstract: | Objective The purpose of this study is to analyze clinical aspects and disease-free survival (DFS) in children less than 3 years of age diagnosed with low-grade astrocytoma. Methods In a period of 24 years (1980–2004), a total of 43 (5.4%) children were registered with these characteristics. Twenty-three patients had pilocytic astrocytoma, 18 diffused, and 2 mixed. Thirty-one (72.1%) children had incomplete surgical tumor resection and 12 (27.9%) had a complete tumor resection. Twelve (27.9%) patients had cranial radiotherapy and 17 (39.5%) received chemotherapy. Overall survival was recorded in 23 (53%). DFS was 50% at 250 months of follow-up for the whole group. DFS for the supratentorial group was 60% at 250 months, whereas, for the infratentorial, it was 22% at 120 months (p = 0.008). Conclusion The only favorable prognostic pattern was the supratentorial presentation. Radiotherapy and chemotherapy did not alter the outcome. |
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| Keywords: | Brain tumors Astrocytoma Low grade Three years old Outcome |
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