纳洛酮对血管性痴呆大鼠学习与记忆能力影响的研究

目的：研究纳洛酮对血管性痴呆大鼠学习与记忆能力的影响。方法：采用结扎大鼠双侧颈总动脉方法，制备血管性痴呆模型后随机分为模型组和治疗组，另设假手术组。治疗组大鼠连续7天腹腔注射纳洛酮后分组对动物进行Morris水迷宫训练。结果：（1）在Morris水迷宫隐匿平台 训练中，假手术组动物的逃避潜伏期最短，治疗组动物 的逃避潜伏期比模型组明显缩短（P＜0．05）；（2）探索实验中假手术组穿越次数最多，治疗组穿越次数又多于模型组（P＜0．05）；（3）可见平台学习中，三组动物 的逃避潜伏期无明显组间差别（P＞0．05）。结论：纳洛酮可明显改善血管性痴呆大鼠的学习记忆能力。

Effect of naloxone on learning and memory in rats with vascular dementia

Objective To study the effect of naloxone on spatial learning and memory in rats with vascular dementia (VD).Methods The rat model of vascular dementia was made by a permanent bilateral occlusion of both common carotid arteries using 2-VO method, the successful models were divided at random into two group:naloxone treated group and VD group, the former received naloxone injection(i.p.)for 7 days,while the latter and sham-operated group received the same volume saline injection in the same time. Then all the animals were trained in Morris Water Maze orderly for 6 days to test the latencies.Results (1) The latencies of sham-operated group animals in the submerged platform task training were shortest in all groups, while the latencies of naloxone treated group were significantly shorter than that of VD group animals (P<0.05).(2) The times of passing through the submerged platform of sham-operated group animals were most in three group in search platform task training,the times of naloxone treated group were significantly more than that of VD group (P<0.05).(3)In the visible platform task training the latencies were counted,there was no significant difference in three groups(P>0.05).Conclusion Naloxone can facilitate the spatial learning and memory in rats with vascular dementia.