Discordance between aeroallergen specific serum IgE and skin testing in children younger than 4 years |
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| Authors: | Gabriele de Vos Ramin Nazari Denisa Ferastraoaru Purvi Parikh Rebecca Geliebter Yikania Pichardo Andrew Wiznia David Rosenstreich |
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| Affiliation: | 1. Department of Endocrinology, Odense University Hospital, Odense, Denmark;2. Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark;3. Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, Copenhagen, Denmark;4. The Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;5. Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark;6. Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark;7. Department of Gynecology and Obstetrics, Hilleroed hospital, Hilleroed, Denmark;8. Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark;9. Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen, Denmark;10. Medical Research Lab., Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;11. Section of Molecular Diabetes & Metabolism, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark;12. Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark |
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| Abstract: | BackgroundAtopic sensitization to aeroallergens in early life has been found to be a strong risk factor for the development of persisting asthma in young children with recurrent wheeze.ObjectiveTo assess the yield of skin prick test (SPT) compared with allergen specific serum IgE (sIgE) testing at identifying aeroallergen sensitization in atopic children younger than 4 years.MethodsConcordance between SPT and allergen-specific sIgE testing for 7 common aeroallergens was analyzed in 40 atopic inner-city children 18 to 48 months of age (mean [SD], 36 [9] months) with recurrent wheezing and family history of asthma and/or eczema.ResultsIn 80% of children one or more allergen sensitizations would have been missed if only SPT had been performed, and in 38% of children one or more sensitizations would have been missed if only sIgE testing had been performed. Agreement between the SPT and sIgE test was fair for most allergens (κ = ?0.04 to 0.50), as was correlation between sIgE levels and SPT grade (ρ = 0.21 to 0.55). Children with high total sIgE (≥300 kU/L) were more likely to have positive sIgE test results, with negative corresponding SPT results (P = .02).ConclusionOur study revealed a significant discordance between allergen-specific SPT and sIgE testing results for common aeroallergens, suggesting that both SPT and sIgE testing should be performed when diagnosing allergic sensitization in young children at high risk of asthma.Trial Registrationclinicaltrials.gov Identifier: NCT01028560 |
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