Visual Assessment of Brain Magnetic Resonance Imaging Detects Injury to Cognitive Regulatory Sites in Patients With Heart Failure |
| |
| Authors: | Alan Pan Rajesh Kumar Paul M Macey Gregg C Fonarow Ronald M Harper Mary A Woo |
| |
| Institution: | 1. School of Nursing, University of California, Los Angeles, California;2. Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California;3. Department of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California;4. Brain Research Institute, University of California, Los Angeles, California;1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria;2. Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands;3. Department of Cardiology and Pneumology, University of Goettingen, Goettingen, Germany;4. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria;5. Coordination Center for Clinical Trials, University of Leipzig, Leipzig, Germany;6. Department of Cardiology, Charité-Universitätsmedizin Berlin, Germany;7. Department of Cardiology, Medical University of Graz, Austria;8. Brahms, Hennigsdorf, Germany;9. Synlab Center of Laboratory Diagnostics, Heidelberg, Germany;10. Mannheim Institute of Public Health, Medical Faculty Mannheim, Ruperto Carola University Heidelberg, Mannheim, Germany;1. Faculty of Nursing, Midwifery and Health, University of Technology, Sydney, Australia;2. Management of Cardiac Function, Royal North Shore Hospital, St Leonards, Australia;3. Management of Cardiac Function, Manly and Mona Vale Hospitals, Sydney, Australia;4. Management of Cardiac Function, Ryde Hospital, Sydney, Australia;5. Management of Cardiac Function, Hornsby Hospital, Sydney, Australia;6. Cardiovascular Research Centre, Australian Catholic University, Melbourne, Australia;1. Department of Old Age Psychiatry, University Psychiatric Centre, Katholieke Universiteit Leuven, Leuven, Belgium;2. Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, Katholieke Universiteit Leuven and University Hospitals Leuven, Leuven, Belgium;3. Laboratory for Cognitive Neurology, Katholieke Universiteit Leuven, Leuven, Belgium;4. Neurology Department, University Hospitals Leuven, Leuven, Belgium;5. Translational MRI, Department of Imaging and Pathology, Katholieke Universiteit Leuven and University Hospitals Leuven, Leuven, Belgium;1. Emergency Department, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, Spain |
| |
| Abstract: | BackgroundHeart failure (HF) patients exhibit depression and executive function impairments that contribute to HF mortality. Using specialized magnetic resonance imaging (MRI) analysis procedures, brain changes appear in areas regulating these functions (mammillary bodies, hippocampi, and frontal cortex). However, specialized MRI procedures are not part of standard clinical assessment for HF (which is usually a visual evaluation), and it is unclear whether visual MRI examination can detect changes in these structures.Methods and ResultsUsing brain MRI, we visually examined the mammillary bodies and frontal cortex for global and hippocampi for global and regional tissue changes in 17 HF and 50 control subjects. Significantly global changes emerged in the right mammillary body (HF 1.18 ± 1.13 vs control 0.52 ± 0.74; P = .024), right hippocampus (HF 1.53 ± 0.94 vs control 0.80 ± 0.86; P = .005), and left frontal cortex (HF 1.76 ± 1.03 vs control 1.24 ± 0.77; P = .034). Comparison of the visual method with specialized MRI techniques corroborates right hippocampal and left frontal cortical, but not mammillary body, tissue changes.ConclusionsVisual examination of brain MRI can detect damage in HF in areas regulating depression and executive function, including the right hippocampus and left frontal cortex. Visual MRI assessment in HF may facilitate evaluation of injury to these structures and the assessment of the impact of potential treatments for this damage. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
