Serum Uric Acid Levels in Relation to Bone-Related Phenotypes in Men and Women |
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| Authors: | Chanika Sritara Boonsong Ongphiphadhanakul Laor Chailurkit Sukit Yamwong Wipa Ratanachaiwong Piyamitr Sritara |
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| Institution: | 1. Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;2. Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;3. Medical and Health Office, Electricity Generating Authority of Thailand, Nonthaburi, Thailand;1. Division of Cardiovascular Medicine, TOHO University Ohashi Medical Center, Japan;2. Division of Nephrology, TOHO University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, Japan;3. Cardiology Division, National Center for Global Health and Medicine, Japan;1. Department of Medicine, University of Manitoba, Winnipeg, MB, Canada;2. Department of Medicine, University of Alberta, Edmonton, AB, Canada;1. Park Nicollet Osteoporosis Center and Institute for Research and Education, Minneapolis, MN, USA and Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA;2. Beth Israel Deaconess Medical Center, Boston, MA, USA;3. Department of Medicine, University of Chicago, Chicago, IL, USA;4. Department of Epidemiology, Graduate school of Public Health, University of Pittsburgh, Pittsburgh, PA, USA;5. San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA;6. Division of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA;7. Bone and Mineral Unit, Oregon Health and Science University, Portland, OR, USA;8. Departments of Family and Preventive Medicine and Internal Medicine, University of California at San Diego, San Diego, CA, USA;9. Division of Epidemiology, University of Minnesota, Minneapolis, MN, USA and Minneapolis Veterans Administration Medical Center, Minneapolis, MN, USA;1. Department of Physiology, University of California, Los Angeles, United States;2. Department of Medicine, University of California, Los Angeles, United States;3. Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, United States;4. Department of Bioengineering, University of California, Los Angeles, United States;1. Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA;2. Division of Endocrinology, Department of Medicine, University of Chicago, Chicago, IL, USA;3. Department of Rheumatology, Orthopedic and Rheumatology Institute, Cleveland, OH, USA;4. Division of Endocrinology, Department of Medicine, St Rita Hospital, Lima, OH, USA;5. Division of Rheumatology, Department of Medicine, Geisinger Medical Center, Danville, PA, USA;6. Park Nicollet Institute for Research and Education and University of Minnesota, Minneapolis, MN, USA |
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| Abstract: | Serum uric acid levels have recently been found to be associated with bone mineral density (BMD) in elderly males. The purpose of the present study was to investigate the relationship between bone-related phenotypes and serum uric acid levels in young and middle-aged males and females. Subjects consisted of 1320 males and 485 females aged 25–54 yr. Bone densitometry and quantitative ultrasonometry (QUS) were performed on each subject. Serum uric acid and biochemical markers of bone turnover were measured in fasting serum samples. When adjusted for covariates including age, body weight, and serum creatinine in multiple linear regression models, it was found that there was a positive association between uric acid levels and BMD in males at the lumbar spine (p < 0.05). The association between uric acid levels and BMD was found in females after controlling for age, body weight, and serum creatinine at the femoral neck, but in the opposite direction (p < 0.05). Uric acid levels were related to the stiffness index (SI) as assessed by QUS in males, independent of age, body weight, and serum creatinine (p < 0.05). No association between uric acid and SI in females was found. The present study demonstrated a positive association in males between serum uric acid levels and BMD, and SI from QUS, suggesting a beneficial influence of uric acid on both the quantity and quality of bone in males. |
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