Precision Errors,Least Significant Change,and Monitoring Time Interval in Pediatric Measurements of Bone Mineral Density,Body Composition,and Mechanostat Parameters by GE Lunar Prodigy |
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| Authors: | Maciej Jaworski Pawel Pludowski |
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| Affiliation: | 1. Cleveland Clinic Center for Human Nutrition, Cleveland, OH, USA;2. Department of Endocrinology, Diabetes, and Metabolism, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA;1. Department of Medicine, University of Manitoba, Winnipeg, MB, Canada;2. School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada;3. Consulting Statistician, Gothenburg, Sweden;4. Osteoporosis Centre, Northern General Hospital, Sheffield, UK;5. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK;1. Department of Medicine, University of Manitoba, Winnipeg, MB, Canada;2. Department of Medicine, University of Alberta, Edmonton, AB, Canada;1. Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA;2. Division of Endocrinology, Department of Medicine, University of Chicago, Chicago, IL, USA;3. Department of Rheumatology, Orthopedic and Rheumatology Institute, Cleveland Clinic Foundation, Cleveland, OH, USA;4. Division of Endocrinology, Deparatment of Medicine, St Rita Hospital, Lima, OH, USA;5. Division of Rheumatology, Department of Medicine, Geisinger Medical Center, Danville, PA, USA;6. Park Nicollet Institute for Research and Education and University of Minnesota, Minneapolis, MN, USA;1. New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA;2. Section of Endocrinology and Metabolism, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA, USA;3. Columbia University College of Physicians and Surgeons, New York, NY, USA;4. Beth Israel Deaconess Medical Center, Boston, MA, USA;5. Stanford University School of Medicine, Stanford, CA, USA;6. Oregon Osteoporosis Center, Portland, OR, USA;7. Colorado Center for Bone Research, Lakewood, CO, USA;8. Vanderbilt University Medical Center, Nashville, TN, USA;9. National Osteoporosis Foundation, Washington, DC, USA |
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| Abstract: | Dual-energy X-ray absorptiometry (DXA) method is widely used in pediatrics in the study of bone density and body composition. However, there is a limit to how precise DXA can estimate bone and body composition measures in children. The study was aimed to (1) evaluate precision errors for bone mineral density, bone mass and bone area, body composition, and mechanostat parameters, (2) assess the relationships between precision errors and anthropometric parameters, and (3) calculate a “least significant change” and “monitoring time interval” values for DXA measures in children of wide age range (5–18 yr) using GE Lunar Prodigy densitometer. It is observed that absolute precision error values were different for thin and standard technical modes of DXA measures and depended on age, body weight, and height. In contrast, relative precision error values expressed in percentages were similar for thin and standard modes (except total body bone mineral density [TBBMD]) and were not related to anthropometric variables (except TBBMD). Concluding, due to stability of percentage coefficient of variation values in wide range of age, the use of precision error expressed in percentages, instead of absolute error, appeared as convenient in pediatric population. |
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