基于“脾为之卫”理论探讨肠道黏膜免疫与类风湿关节炎的中医机制

“脾为之卫”理论认为,脾胃助生卫气,卫气御外防护,形成人体屏障,即脾行卫之功.脾不足是痹证发生的根本原因,感受风寒湿邪是外因,痰、瘀既是直接病因也是病理产物.由于卫气的生成需经过饮入胃一胃腐熟一脾运化一小肠泌别一大肠传化五个步骤,故大肠功能完整亦是脾行使卫外防御机能的基础.西医研究证实肠道黏膜免疫功能紊乱是类风湿关节炎...

Discussion on the TCM Mechanism of Intestinal Mucosal Immunity and Rheumatoid Arthritis Based on the Theory of"Spleen as the Defense of Zang-Fu Viscera"

According to the theory of"spleen as the defense of zang-fu viscera",the spleen and stomach help to produce Weiqi,and Weiqi resists pathogenic qi,forming the body barrier.Spleen deficiency is the root cause of Bi syndrome.Wind,cold and dampness pathogen attacking the body is the external cause.Phlegm and blood stasis are not only the direct cause,but also the pathological product.Because the formation of Weiqi needs to go through five steps:food into the stomach-stomach digestion-spleen transportation-small intestine secretion-large intestine transmission,so the integrity of large intestine function is the basis of spleen′s defense function.Western medicine studies have confirmed that intestinal mucosal immune dysfunction is one of the main characteristics of rheumatoid arthritis,and the immune site of intestinal mucosa is in the intestine,and its function belongs to the spleen,which is highly consistent with the theory of"spleen as the defense of zang-fu viscera".