Detection of cytokeratins in ghost cells of calcifying cystic odontogenic tumor indicates an altered keratinization and hair follicle differentiation for their development |
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| Authors: | Estela Kaminagakura Patrícia Luciana Batista Domingos Marize Raquel Diniz da Rosa Adriano Mota Loyola Sérgio Vitorino Cardoso Maria Cândida de Almeida Lopes Paulo Rogério Ferreti Bonan Paulo Rogério de Faria |
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| Affiliation: | 1. Dental School, Universidade Estadual Paulista, UNESP, São José dos Campos, São Paulo, Brazil;2. Master Program, Universidade Estadual de Montes Claros, UNIMONTES, Montes Claros, Minas Gerais, Brazil;3. Dental School, Universidade Federal da Paraíba, UFPB, João Pessoa, Paraíba, Brazil;4. Dental School, Universidade Federal de Uberlândia, UFU, Uberlândia, Minas Gerais, Brazil;5. Dental School, Universidade Federal do Piauí, UFPI, Teresina, Piauí, Brazil;6. Institute of Biomedical Science, Universidade Federal de Uberlândia, UFU, Uberlândia, Minas Gerais, Brazil;1. Department of Orthopedic Surgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;2. Institute of Orthopedic Research, Zhejiang University, Hangzhou 310009, China;3. Department of Orthopaedic Surgery, Yiwu Central Hospital, Affiliated Hospital of Wenzhou Medical College, Yiwu 322000, China;1. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, São Paulo, Brazil;2. Department of Immunology, Science Biological Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais;3. Department of Oral Pathology and Oral Biology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa |
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| Abstract: | Calcifying cystic odontogenic tumors (CCOTs) are benign cystic lesions of odontogenic origin characterized by an ameloblastoma-like epithelium and the presence of a group of cells named ghost cells. The pattern of cytokeratin (Ck) expression on these lesions remains unclear and needs to be clarified. To this end, the expression of Ck6, Ck13, Ck14, Ck18, and Ck19 in the epithelium lining of 7 cases of CCOTs was evaluated by immunohistochemistry. For this, the epithelium lining was divided into 3 distinct regions: basal layer, suprabasal layer, and the compartment composed of ghost cells. In this study, 6 cases (85.7%) were classified as type 1 and 1 (14.3%) as type 4. All cases were negative for Ck13 and Ck18, despite the epithelial layer, as well as in the ghost cells. Ck6 was only positive in the ghost cells. Positivity for Ck14 and Ck19 was found in the basal and suprabasal layers, including the ghost cells. The results showing positivity for Ck14 and Ck19 in all of the analyzed cases reinforce CCOT as being of odontogenic origin, and the restricted expression of Ck6 in the ghost cells may be indicative that these cells suffer an altered differentiation into hair follicles in CCOTs. |
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