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Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP
Authors:Weiguo Yao  Yanlu Zhang  Rukhsana Jabeen  Evelyn T Nguyen  David S Wilkes  Robert S Tepper  Mark H Kaplan  Baohua Zhou
Institution:1. Department of Pediatrics, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA;2. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA;3. Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA;4. Institute of Biotechnology, Zhejiang University, Hangzhou 310029, China
Abstract:
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  • Highlights? TSLP induces IL-9 from human and mouse Th9 cells ? TSLP enhances Th9-mediated allergic lung inflammation ? Blocking IL-9 attenuates TSLP-induced lung inflammation
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