Carcinoma of the fallopian tube: Results of a multi-institutional retrospective analysis of 127 patients with evaluation of staging and prognostic factors |
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| Authors: | Isabel Alvarado-Cabrero Simona Stolnicu Takako Kiyokawa Kyosuke Yamada Takashi Nikaido Héctor Santiago-Payán |
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| Affiliation: | 1. Department of Obstetrics & Gynecology (791), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, the Netherlands;2. Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands;3. Department of Obstetrics and Gynecology, TweeSteden Hospital, Tilburg, the Netherlands;4. Department of Pathology, St Elisabeth Hospital, Tilburg, the Netherlands;1. Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark;2. Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;3. Department of Gynecology & Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;4. Department of Pathology, Copenhagen University Hospital, Kettegård Allé 30, 2650 Hvidovre, Denmark;5. Center of Fetal Medicine, Department of Obstetrics, Juliane Marie Centre, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark;6. Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;7. Gynecologic Clinic, Juliane Marie Centre, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark;1. Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;2. Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;3. Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;4. School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;5. Division of Thoracic Surgery, Department of Surgery, and Cancer Center, E-DA Hospital, Kaohsiung, Taiwan;6. Department of Health Management, I-Shou University, Kaohsiung, Taiwan;7. School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan;8. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan;9. Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan;10. Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;11. Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan;12. Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan;13. National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung, Taiwan;14. Biomedical Engineering and System Bioinformatics Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan |
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| Abstract: | The aim of this study was to determine the impact of prognostic factors in primary fallopian tube carcinoma (PFTC). All cases of PFTC diagnosed between 1990 and 2010 were retrieved from the files of 6 academic centers. The cases were staged according to a modification of the International Federation of Obstetrics and Gynecology staging system proposed by Alvarado-Cabrero et al (Gynecol Oncol 1999; 72: 367–379). One hundred twenty-seven PFTC cases were identified. The mean age of the patients was 64.2 years. Stage distribution was as follows: 72 (57%), stage I; 19 (15%), stage II; 28 (22%), stage III; and 8 (6.2%), stage IV. Depth of infiltration of the tubal wall was an independent prognostic factor in stage I cases (P < .001). Carcinomas located in the fimbriated end even without invasion had a worse prognosis than did carcinomas involving the tubal portion of the organ. The presence of vascular space invasion correlated with the depth of tubal wall invasion (P = .001) and the presence of lymph node metastases (P = .003). Tumor grade significantly correlated with survival (P < .0001), but histologic type was of marginal significance and only if it was grouped as nonserous/non–clear cell vs serous/clear cell (P = .04). The depth of invasion of the tubal wall and the presence of carcinoma in the fimbriated end even without invasion are important prognostic indicators. The modified International Federation of Obstetrics and Gynecology staging system should be used on a routine basis in all carcinomas of the fallopian tube. |
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