Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women |
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| Authors: | Hyun-Seok Jin Bo-Young Kim Jeonghyun Kim Kyung-Won Hong Suk-Yul Jung Yun-Seok Lee Dam Huh Bermseok Oh Yoon-Sok Chung Seon-Yong Jeong |
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| Affiliation: | 1. Department of Medical Genetics, Ajou University School of Medicine, Suwon, Republic of Korea;2. Division of Epidemiology and Health Index, Center for Genome Science, Korea Centers for Disease Control & Prevention, Cheongwon, Republic of Korea;3. Department of Biomedical Laboratory Science, Molecular Diagnosis Research Institute, Namseoul University, Cheonan, Republic of Korea;4. Department of Health Administration, Namseoul University, Cheonan, Republic of Korea;5. Dongwoodang Pharmaceutical Co., Ltd, Kyeongsan, Republic of Korea;6. Department of Biomedical Engineering, School of Medicine, Kyung Hee University, Seoul, Republic of Korea;7. Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea |
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| Abstract: | BackgroundEmerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans.MethodsWe performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY1 gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects).ResultsAll four SPRY1 gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p = 0.0087) and percentage abdominal fat (p = 0.047), and osteoporosis (odds ratio = 1.50; p = 0.025) in the recessive genetic model.ConclusionsOur results support a previous finding in conditional Spry1 gene knockout mice and suggest that the SPRY1 gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans. |
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