1. Departments of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA;2. Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA;3. Department of Surgery, The University of Chicago, Chicago, IL 60637, USA;4. Herbert Irving Comprehensive Cancer Center, Departments of Pathology & Cell Biology and Microbiology & Immunology, Columbia University, New York, NY 10032;5. Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;6. Discovery Immunology, Genentech, San Francisco, CA 94080, USA