Sarcopenia is Related to Increased Risk for Low Bone Mineral Density |
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| Authors: | Chia-Hung Wu Kun-Cheh Yang Hao-Hsiang Chang Jo-Fang Yen Ko-Sung Tsai Kuo-Chin Huang |
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| Affiliation: | 1. Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan;2. Department of Family Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan;3. Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan;4. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;5. Division of Geriatric Research, Institute of Population Health Sciences, National Health Research Institutes, Taipei, Taiwan;6. Graduate Institute of Clinical Medical Science, China Medical University, Taipei, Taiwan;1. Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA;2. Division of Endocrinology, Department of Medicine, São Paulo Federal University, São Paulo, Brazil;1. Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT, USA;2. Yale-New Haven Hospital, New Haven, CT, USA;3. Department of Surgery, Yale University, School of Medicine, New Haven, CT, USA;1. Department of Otolaryngology-Head and Neck Surgery, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada;2. Department of Surgery, McMaster University, Hamilton, Ontario, Canada;1. McMaster University, Hamilton, Ontario, Canada;2. University of Florence, Florence, Italy;3. Harvard University, Cambridge, MA, USA;4. Columbia University, New York, NY, USA |
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| Abstract: | Lean body mass is positively correlated with bone mineral density (BMD). The association between sarcopenia and BMD is less studied. The aim of the study is to investigate the association between sarcopenia and abnormal BMD. A total of 600 community residents aged 40–85 yr (mean = 63.63 ± 10.12) from Taipei, Taiwan were included. Abnormal and normal BMD groups were categorized by T-score of femoral neck and lumbar spine (L2–L4) measured by dual-energy X-ray absorptiometry. Skeletal muscle mass (SM) index (SMI) was obtained from SM divided by height squared using bioelectrical impedance analysis (BIA) method. Sarcopenia was defined as SMI less than 8.87 kg/m2 in men and 6.42 kg/m2 in women according to previous Taiwanese sarcopenia study. The association between BMD groups and sarcopenia was examined using binary logistic regression analyses after controlling potential confounders. Subjects with sarcopenia were at higher risk for low BMD (odds ratio (OR) = 1.59, 95% confidence interval (CI) = 1.06–2.39 for femoral neck BMD and OR = 1.72, 95% CI = 1.09–2.72 for lumbar BMD) compared with the nonsarcopenia group. Even in different gender groups with age categorized, sarcopenia was still an important independent factor in female group. The least square (LS) means of BMD of femoral neck and lumbar spine were significantly lower in sarcopenia group. The risk of low BMD increased significantly with sarcopenia. |
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