CD34low and SMAhigh represent stromal signature in uterine cervical cancer and are markers for peritumoral stromal remodeling |
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| Authors: | Lars-Christian Horn Carolin Schreiter Anika Canzler Karoline Leonhardt Jens Einenkel Bettina Hentschel |
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| Institution: | 1. Institute of Pathology, Division of Breast, Gynecologic & Perinatal Pathology, University of Leipzig, Leipzig, Germany;2. Department of Obstetrics and Gynecology (Institute of Trier), Division of Surgical Gynecologic Oncology, University of Leipzig, Leipzig, Germany;3. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany;1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China;2. Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China;1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China;2. Department of Obstetrics and Gynecology, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, PR China;3. Department of Obstetrics and Gynecology, Wuhan Central Hospital, Wuhan 430014, PR China;1. Center of Chronic Immunodeficiency, University Medical Center Freiburg, Germany;2. Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Germany;3. Institute for Transfusion Medicine, University of Ulm, Ulm, Germany;4. Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Ulm, Germany;5. Department of Clinical Genetics and Genomics, Royal Brompton and Harefield NHS Foundation Trust, Imperial College London, UK;6. CECAD Research Center, Institute for Genetics, University of Cologne, Cologne, Germany;7. Department of Pediatrics, and Translational Gastroenterology Unit, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK |
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| Abstract: | Peritumoral desmoplastic stromal reaction (DSR) with myofibroblastic phenotype may be of prognostic impact in uterine cervical carcinoma. The present study evaluates the immunostaining (CD34 and smooth muscle actin; SMA) of 97 squamous cell cancers. Staining was scored as low/negative (< 5% stroma positive), moderate (patchy/focal expression, 5%-50%), or high (diffuse expression throughout peritumoral stroma, > 50%) and DSR as negative/weak and moderate/strong. The staining results were correlated to patient survival. Of the cases, 78.3% showed a decreased of CD34 (< 5% stromal positivity) and 71.9% an increased SMA staining with more than 50% SMA positive stromal cells. Tumors representing moderate/strong DSR showed a significant decreased CD34 (P = .001) and an increased but not statistically significant SMA staining (P = 0.345). Cases with low CD34 and high SMA staining showed reduced 5-year overall survival when compared to cases with high CD34 and low SMA positivity (59.9 vs 81.0%; P = 0.025 and 64.6 vs 81.1%; P = 0.243). Peritumoral stromal response in cervical carcinoma is immunohistochemically characterized by CD34low/SMAhigh and associated reduced overall survival. |
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