Opioid peptides modulate secretion of the basic determinants of bile secretion

The effects of the synthetic opioid peptide dalargin and the antagonist of opiate receptors naloxone hydrochloride on the rate of bile secretion and concentration of bile acids and sodium ions is studied in rats. It is shown that the substances with opioid activity insignificantly raise the rate of bile secretion and concentration of the studied compounds. It is suggested that the secretion of the carbonate ion and glutathione increase under these conditions. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 498–500, May, 1997