| 盐酸曲马多缓释片的人体药代动力学及相对生物利用度 |
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| 引用本文： | 刘会臣 胡玉钦. 盐酸曲马多缓释片的人体药代动力学及相对生物利用度[J]. 中国药房, 1999, 10(4): 170-171 |
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| 作者姓名： | 刘会臣 胡玉钦 |
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| 作者单位： | 白求恩国际和平医院临床药理室!石家庄市０５００８２ |
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| 摘 要： | 目的：研究两种盐酸白马多缓释片的药代动力学及相对生物利用度。方法：随机交叉试验设计，健康志愿者口服单剂量和多剂量盐酸曲马多缓释片，气相色谱法测定血清中盐曲马多的浓度。结果：两药ＡＵＣｏ—ｔ、Ｔｍａｘ、Ｃｍａｘ等药代动力学参数均无显著性差异。结论：两药具有生物等效性。
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| 关 键 词： | 盐酸曲马多缓释片 药代动力学 相对生物利用度 气相色谱 |
Clinical Pharmacokinetics and Relative Bioavailability of Tramadol Hydrochloride Sustained-released Tablets |
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| LIU Huichen, HU Yuqin, WANG Jian,LI Xinfang, HOU Yanning. Clinical Pharmacokinetics and Relative Bioavailability of Tramadol Hydrochloride Sustained-released Tablets[J]. China Pharmacy, 1999, 10(4): 170-171 |
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| Authors: | LIU Huichen HU Yuqin WANG Jian LI Xinfang HOU Yanning |
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| Abstract: | OBJECTIVE:To study the clinical pharmacokinetics and relative bioavailability of two kinds of tramadol hydrochloride sustained-released tablets.METHOD:In a randomized cross-overdesign,the study was carried out in healthy volunteers after asingle oral dose and multiple oral doses.The serum concentrations oftramadol hydrochloride were measured by gas chromatography. RESULTS: There were no significant differences in all pharmacokineticparameters between two preparations,expecially AUCo-t,Tmax and Cmax.CONCLUSION:The two preparations were bioequivalent. |
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| Keywords: | tramadol hydrochloride sustained-released tablet pharmacokinetics relative bioavailability gas chromatography. |
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