维生素A对4~6岁儿童白细胞数量及其分类的影响

目的 了解东莞市4~6岁儿童维生素A缺乏现状,以及维生素A水平对白细胞计数及其分类的影响,为进一步研究提供理论支持。方法 采用随机抽样调查的方法,于2017年4-8月选取东莞市无现患疾病的4~6岁儿童进行血常规及维生素A浓度检测,其中五分类血常规采用全自动血细胞分析仪检测;维生素A浓度采用高效液相色谱法(HPLC)检测。结果 维生素A缺乏人数占总调查人数的34.97%(539/1 687)。男童嗜酸粒细胞计数、嗜碱粒细胞计数及单核细胞计数高于女童。随着年龄增长,单核细胞及淋巴细胞数量逐渐降低。4岁及6岁组儿童维生素A缺乏组淋巴细胞数量低于维生素A正常组;而在5岁组儿童,维生素A缺乏组中性粒细胞高于维生素A正常组。结论 东莞市4~6岁儿童维生素A缺乏状况仍较严重,并可对淋巴细胞计数及中性粒细胞计数产生影响。

Effect of vitamin A on the count and classification of leukocyte of children aged 4~6

Objective To know about the status of vitamin A deficiency of 4 to 6-year-old children in Dongguan city, and the effects of vitamin A on count and classification of leukocyte. Methods A sampling survey was used to selected healthy children aged 4~6 in this study, and full blood differential counts were determined by blood routine examination,vitamin A concentration were tested by High Performance Liquid Chromatography(HPLC). Results The percentage of vitamin A deficiency was 34.97%(539/1 687). The count of eosinophils, basophils and mononuclear cells of boys was higher than thase of girls. The number of monocytes and lymphocytes decreased with age. The count of lymphocyte in vitamin A deficiency group was less than that of vitamin A normal group in 4-year-old and 6-year-old children. While the count of neutrophils was higher in the vitamin A deficiency group than that of the vitamin A normal group in 5-year-old children. Conclusion The situation of vitamin A deficiency in preschool children in Dongguan city is still serious, and the vitamin A deficiency can affect the count of lymphocyte and neutrophils.