益生元与肠道粘膜免疫及婴幼儿过敏性疾病的研究进展

早期预防过敏性疾病对于阻断过敏进程,提高儿童生活质量非常重要。近期较多研究显示,益生元可以模拟母乳中低聚糖,通过多种途径参与肠道粘膜免疫,如影响肠道菌群的种类及数量、促进结肠内短链脂肪酸产生等,从而对过敏性疾病的发生产生影响。虽然对于益生元调节免疫及预防过敏的结论尚不完全一致,但越来越多的证据显示益生元可能是预防过敏性疾病重要措施之一。

Pesearch progress on the effect of prebiotics on intestinal mucosal immunity and allergic diseases

Early preventive strategies of allergic diseases are beneficial to block the allergy march and to improve the quality of life. Most studies have shown that prebiotics, similar to human milk oligosacharides, might involve into intestinal mucosal immunity regulation by impacting intestinal flora species or quantity, producing short chain fatty acids and so on, thereby triggering allergic diseases. Although there is no consistent conclusion about the effect of prebiotics on immunity regulation and allergy prevention, more and more evidence show that prebiotics intervention seems to be one of the most important strategies to prevent allergic diseases.