18月龄幼儿血清维生素D水平与神经发育的临床观察

目的 探讨18月龄幼儿血清维生素D(VitD)水平对神经发育的影响,为VitD的预防和干预提供理论依据。方法 2014年6月-2017年5月对1 283例18月龄幼儿进行血清VitD含量检测,将其分为缺乏、不足、正常组;采用上海复旦大学儿科医院0~6岁发育筛查测验(DST),比较三组幼儿发育商(DQ)和在运动、社会适应、智力能区的差异。结果 1)18月龄幼儿血清VitD缺乏、不足、正常率分别为3.35%、30.16%、66.48%,不同性别幼儿血清VitD的分布 ( 缺乏、不足、正常) 差异无统计学意义(t=3.507,P＞0.05) 。2)VitD缺乏组在智力能区得分低于正常组,差异有统计学意义(t=5.657,P<0.05)。结论 VitD缺乏对幼儿的神经心理发育有不良影响,应及时给予合理补充。

Clinical observation of the effect of serum vitamin D levels on the neural development in 18 months old infants

Objective To explore the effect of serum vitamin D levels on the neural development in 18 months old infants,and to provide theory basis for prevention and intervention. Methods Serum vitamin D levels of 1 283 infants aged 18 months were detected and divided into three groups (deficiency,insufficiency,and normal group)from June 2014 to May 2017.They were assessed with Developmental Screen Test (DST),an intellectual developmental screening test developed by Pediatric Hospital of Fudan University in Shanghai,and the differences of developmental quotient,exercise capacity,social adaptation,intelligence of three groups were compared. Results 1)The detection rates of vitamin D deficiency,insufficiency,and normal range were 3.35%,30.16% and 66.48% respectively.The difference on serum vitamin D was not significant in three groups (t=3.507,P>0.05).2)The values of the intelligence in the deficiency group were significantly lower than those of normal group (t=5.657,P<0.05). Conclusion Vitamin D dificiency has a negative effect on neuropsychological development,and Vitamin D should be promptly added to infants of vitamin D deficiency.