低敏配方喂养的牛奶过敏儿童生长及体成分发展的纵向随访性研究

目的 纵向观察生后早期低敏配方(HF)喂养的牛奶过敏(CMA)婴儿的体格生长特别是体成分(BC)的发展情况,以便对该群体进行营养与生长的评估和监测。方法 于2014年1月-2015年9月将60名HF喂养且不满4月龄的CMA婴儿纳入本次研究。给婴儿进行常规健康体检直至其满1周岁,并在6月龄及此之前采用PEA POD^®婴儿体成分测量仪、12月龄采取皮褶厚度测量的方法评估其BC发展。结果 婴儿的平均入组年龄为(2.9±1.0)个月。与年龄配对的健康对照组儿童相比,HF喂养的CMA婴儿在6～12月龄的年龄别体重、9～12月龄的身长别体重Z评分均更低;体脂百分比在6月龄(26.2% vs 30.3%,P=0.015)和12月龄(23.8% vs 27.1%,P=0.028)时均明显落后;平均脂肪组织指数(FMI)较对照组落后至少0.2个单位,但差异无统计学意义(P>0.05)。结论 生后早期HF喂养的CMA婴儿有可能出现体重增长和体脂储存的受损。

Follow-up study of growth and body composition development of hypoallergenic formula-fed children with cow's milk allergy

Objective To longitudinally observe the physical growth, especially body composition (BC) in hypoallergenic formula (HF)-fed children with cow's milk allergy (CMA) in the early birth period. Methods Totally 60 HF-fed children under 4 months old were enrolled in this study from January 2014 to September 2015.Routine physical examinations were conducted till 1 year old. BC was measured using a PEA POD^® Infant Body Composition System during the first 6 months of life and assessed by skinfold anthropometry at 12 months old. Results The average age of infants at enrollment was (2.9±1.0) months old. Compared with healthy control of the same age, HF-fed CMA infants had significantly lower weight-for-age Z scores from 6 to 12 months and weight-for-length Z scores from 9 to 12 months; Also, the percent fat mass of HF-fed CMA infants was significantly lower than that of the control infants at the age of 6 months old (26.2% vs 30.3%,P=0.015) and 12 months old (23.8% vs 27.1%,P=0.028); The mean fat mass index (FMI) was at least 0.2 units lower than that of the control infants, but the difference was not statistically significant(P＞0.05). Conclusion Infants with CMA, who are HF-fed in early period after birth, is likely to have weight gain and impaired and body fat accumulation.