| 注射用葫芦素B聚乳酸-羟基乙酸纳米球的制备 |
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| 引用本文： | 王丹蕾,陈大为,郭涛,罗轶凡,赵秀丽,张敬一. 注射用葫芦素B聚乳酸-羟基乙酸纳米球的制备[J]. 沈阳药科大学学报, 2006, 23(6): 335-339 |
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| 作者姓名： | 王丹蕾 陈大为 郭涛 罗轶凡 赵秀丽 张敬一 |
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| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 沈阳军区总医院,药剂科,辽宁,沈阳,110016 |
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| 摘 要： | 目的制备葫芦素B聚乳酸羟基乙酸纳米球。方法采用溶剂挥发法制备葫芦素B聚乳酸羟基乙酸纳米球;以包封率、载药量及粒径为指标,考察处方因素及工艺条件对纳米球质量的影响;采用正交设计法L9(34)对处方进行优化;采用冰箱及室温留样观察法考察制剂稳定性。结果纳米球包封率为85.61%,平均粒径为126 nm;纳米球混悬液在冰箱中4℃保存1个月能基本保持稳定,长期放置则不稳定;纳米球冻干品,室温放置3个月,pH值、粒度分布、包封率和载药量均无明显变化。结论溶剂挥发法制得的葫芦素B聚乳酸羟基乙酸纳米球包封率较高,制备工艺简单。
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| 关 键 词： | 葫芦素B 聚乳酸-羟基乙酸 纳米球 溶剂挥发法 |
| 文章编号： | 1006-2858(2006)06-0335-05 |
| 收稿时间： | 2005-05-19 |
| 修稿时间： | 2005-05-19 |
Preparation of cucurbitacin B loaded poly(lactic-co-glycollic acid)nanospheres |
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| WANG Dan-lei,CHEN Da-wei,GUO Tao,LUO Yi-fan,ZHAO Xiu-li,ZHANG Jing-yi. Preparation of cucurbitacin B loaded poly(lactic-co-glycollic acid)nanospheres[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(6): 335-339 |
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| Authors: | WANG Dan-lei CHEN Da-wei GUO Tao LUO Yi-fan ZHAO Xiu-li ZHANG Jing-yi |
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| Affiliation: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. The General Hospital of Shenyang Military Region, Shenyang 110016, China |
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| Abstract: | Objective To prepare the cucurbitacin B loaded poly(lactic-co-glycollic acid) nanospheres(CuB-PLGA-NS).Methods CuB-PLGA-NS were prepared by solvent-evaporation method.The effects of formulation and preparation factors were studied with the embedding ratio(w_(emb)),drug loading(w_(drug)) and mean diameter(d_m) as references,the formulation was optimized by orthogonal design.Results The encapsulation efficiency and the mean diameter of the nanospheres were 85.61% and 126 nm respectively.Conclusions The encapsulation efficiency of nanospheres is high and the preparation method is simple. |
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| Keywords: | cucurbitacin B poly(lactic-co-glycollic acid) nanospheres solvent-evaporation method |
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