| 人参皂苷Rg1对脑挫伤后大鼠脑内胰岛素样生长因子1表达的影响 |
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| 引用本文： | 李文凯,冉文斌,苏映文,黄飞骏.人参皂苷Rg1对脑挫伤后大鼠脑内胰岛素样生长因子1表达的影响[J].中西医结合学报,2008,6(9). |
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| 作者姓名： | 李文凯 冉文斌 苏映文 黄飞骏 |
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| 作者单位： | 1. 四川大学华西基础医学与法医学院法医病理学教研室,四川成都,610041
2. 四川大学华西基础医学与法医学院基础医学专业实验室,四川成都,610041 |
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| 摘 要： | 目的：探讨人参皂苷Rg1对脑组织挫伤后大鼠脑中胰岛素样生长因子1（insulin—like growth factor-1，IGF-1）表达的影响。方法：Wistar大鼠26只，分为正常对照组（2只），脑挫伤模型组（8只）及人参皂苷Rg1治疗组（16只），在损伤后不同时间点（损伤后6h、12h、2d及6d）分别处死大鼠，使用免疫组化方法观察并检测脑中IGF-1的表达。结果：与对照组相比，脑挫伤模型组损伤后各时间点脑组织中IGF-1的表达有所升高（P〈0．05）；与模型组比较，人参皂苷Rg1治疗组IGF-1的表达明显升高（P％0．05）。结论：人参皂苷Rg1可能通过促进脑挫伤后脑组织IGF-1的表达，促进脑组织的功能恢复。
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| 关 键 词： | 脑挫伤 胰岛素样生长因子1 人参皂苷Rg1 大鼠 |
Effects of ginsenoside Rg1 on expression of insulin-like growth factor-1 in brain of rats with brain contusion |
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| Wen-kai LI,Wen-bin RAN,Ying-wen SU,Fei-jun HUANG.Effects of ginsenoside Rg1 on expression of insulin-like growth factor-1 in brain of rats with brain contusion[J].Journal of Chinese Integrative Medicine,2008,6(9). |
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| Authors: | Wen-kai LI Wen-bin RAN Ying-wen SU Fei-jun HUANG |
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| Institution: | Wen-kai LI1,Wen-bin RAN2,Ying-wen SU1,Fei-jun HUANG1 1. Department of Forensic Pathology,West China College of Preclinical , Forensic Medicine,Sichuan University,Chengdu,Sichuan Province 610041,China 2. Laboratory of Preclinical Medicine,China |
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| Abstract: | Objective:To study the effects of ginsenoside Rg1 on the expression of insulin-like growth factor-1 (IGF-1) in the brain of rats after the experimental brain contusion. Methods: A total of twenty-six Wistar rats were randomly divided into normal control group (n=2), untreated group (n=8) and ginsenoside Rg1 group (n=16). Brain injuries were induced in rats by a mechanical striking device. The brain tissues were extracted at different times after brain injury (6th hour, 12th hour, 2nd day, 6th day), then the... |
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| Keywords: | brain contusion insulin-like growth factor-1 ginsenoside Rg1 rats |
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