Lymphatic Microvessel Density is an Independent Prognostic Factor in Colorectal Cancer |
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Authors: | Kentaro Matsumoto Yoshifumi Nakayama Yuzuru Inoue Noritaka Minagawa Takefumi Katsuki Kazunori Shibao Yosuke Tsurudome Keiji Hirata Naoki Nagata Hideaki Itoh |
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Institution: | (1) Department of Surgery 1, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan |
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Abstract: | Purpose Although lymph node metastasis via lymphatic vessels often is related with an adverse outcome, it is not well known whether lymphatic spread to lymph node needs
the development of the new lymphatic formation. In addition, the correlation between lymphangiogenesis and prognosis has not
been well documented. This study was designed to assess the prognostic value of lymphangiogenesis and lymphatic vessel invasion
in colorectal cancer.
Methods We examined 106 colorectal cancer specimens by immunostaining for podoplanin, lymphatic endothelial specific marker. We evaluated
lymphangiogenesis, as measured by lymphatic microvessel density, and lymphatic vessel invasion. We next investigated the association
of these two parameters with the clinicopathologic findings and prognosis.
Results A significant correlation was observed between high lymphatic microvessel density and positive lymphatic vessel invasion (P = 0.0003). Positive lymphatic vessel invasion was significantly associated with the presence of lymph node metastasis (P = 0.0071). The survival curves demonstrated that both high lymphatic microvessel density and positive lymphatic vessel invasion
were correlated with an adverse outcome (P = 0.0004 and P = 0.009, respectively). In a univariate analysis, high lymphatic microvessel density and positive lymphatic vessel invasion
were negatively associated with the overall survival (P = 0.0011 and P = 0.0118, respectively). Furthermore, high lymphatic microvessel density, but not lymphatic vessel invasion, correlated with
a poor outcome in a multivariate analysis (P = 0.0114).
Conclusions Our data suggested that lymphatic vessel invasion was related with lymph node metastasis and that both lymphatic microvessel
density and lymphatic vessel invasion were related with an adverse outcome in colorectal cancer. Furthermore, lymphatic microvessel
density may be a useful prognostic factor in colorectal cancer.
*Deceased.
The Poster presentation at the meeting of the Japanese Society of Gastroenterology, Sapporo, Japan, October 11 to 14, 2006.
Reprints are not available. |
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Keywords: | Lymphangiogenesis Podoplanin Lymphatic microvessel density Lymphatic vessel invasion Colorectal cancer |
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