Water-soluble optical sensors: keys to detect aluminium in biological environment |
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| Authors: | Ajmal Roshan Unniram Parambil Kavyashree P. Akshay Silswal Apurba Lal Koner |
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| Affiliation: | Bionanotechnology Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, 462066 Bhopal Madhya Pradesh India.; Department of Chemistry, University of Basel, 4058 Basel Switzerland.; Institute of Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, 4132 Muttenz Switzerland |
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| Abstract: | Metal ion plays a critical role from enzyme catalysis to cellular health and functions. The concentration of metal ions in a living system is highly regulated. Among the biologically relevant metal ions, the role and toxicity of aluminium in specific biological functions have been getting significant attention in recent years. The interaction of aluminium and the living system is unavoidable due to its high earth crust abundance, and the long-term exposure to aluminium can be fatal for life. The adverse Al3+ toxicity effects in humans result in various diseases ranging from cancers to neurogenetic disorders. Several Al3+ ions sensors have been developed over the past decades using the optical responses of synthesized molecules. However, only limited numbers of water-soluble optical sensors have been reported so far. In this review, we have confined our discussion to water-soluble Al3+ ions detection using optical methods and their utility for live-cell imaging and real-life application.Aluminium ion plays a critical role in cellular health. Therefore, its detection in water is highly demanding. |
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