妊娠高血压综合征型肾病综合征79例临床分析

目的 :探讨妊高征型肾病综合征的临床特点及对母婴的影响。方法 :回顾分析广州市 5所医院 4年 79例妊高征型肾病综合征 (肾病组 )和 160例重度妊高征 (对照组 )的临床资料。结果 :妊高征型肾病综合征占分娩总数的 0 .19% ,占重度妊高征的14.0 1% ,肾病组发病孕周早。 2 4h尿蛋白、血浆白蛋白、腹水、肾功能受损、早产、小于胎龄儿、新生儿并发症 2组的差异均有高度显著性 (P <0 .0 1)。 2组之间最高收缩压、最高舒张压、病程差异无显著性 (P >0 .0 5 )。肾病组围产儿死亡率高于对照组 ,差异有显著性 (P<0 .0 5 )。结论 :妊高征型肾病综合征发病孕周早 ,母婴预后差 ,适时终止妊娠可减少妊娠期并发症及围产儿发病率和死亡率

Clinical analysis of 79 cases of nephrotic syndrome with pregnancy induced hypertension patients

Objective:To study the clinical features and perinatal outcomes of cases of nephrotic syndrome with pregnancy induced hypertension (NSP).Methods:79 cases of NS PIH (NSP group) and 160 cases of severe pregnancy induced hypertnsion (PIH) (control group) in the past 4 years had been reviewed.Results: The frequency of NSP was 0.19% in total deliveries,and accounted for 14.01% of severe PIH group.The gestation age during which the syndrome diagnosed was earlier in NSP group than that in control group.NSP group was more likely to have heavier proteinuria of 24h,lower serum albumin level,ascites,renal insufficiency,preterm labor,small for gestational age (SGA) infants and the neonatal complications.While there was no difference in blood pressure level and the duration (P>0.05).The perinatal mortality rate was higher in NSP group than that in control group(P<0.05). Conclusions:NSP often occurrs earlier during pregnancy.The perinatal maternal and fetal prognosis is poor.Early diagnosis and timely termination of pregnancy may improve the outcome.