高敏C反应蛋白和血尿酸与冠脉病变程度关系的研究

目的 探讨冠状动脉病变程度与高敏C～反应蛋白（hs-CRP）、血尿酸（UA）的关系.方法 根据造影结果,将269名患者分为急性心肌梗死组42例（AMI）、不稳定性心绞痛组63例（UAP）、稳定性心绞痛组84例（SAP）、对照组80例,所有患者术前均空腹检测高敏C-反应蛋白（hs-CRP）、血尿酸（UA）.结果 冠心病组hs-CRP,UA均显著高于对照组（P＜0.01）,心肌梗死细（AMI）的UA与hs-CRP呈负相关（r=0.459,P＜0.01）,而UAP组UA与hs-CRP呈正相关（r=0.326,P＜0.01）,单支病变、双支病变和3支病变的血尿酸、高敏C反应蛋白水平两两之间比较,差异无显著性.结论 高hs-CRP血症、高UA血症是反映冠心病的独立危险因素,但其水平高低与冠脉病变累及的范围无正相关关系.

Research of the Relationship between Severity of Coronary Disease and Plasma High-Sensitivity Protein and Serum Uric Acid

Objective To evaluate the relationship between severity of coronary lesion and serum high-sensitivity C-reactive protein（hs-CRP） ,uric acid（UA）. Methods Two hundred and sixty-nine patients by coronary angiography,42 patients with AMI（aeute myocar dial infarction） ,63 patients with UAP（ unstable angina pectoris）, 84 with SAP（stable angina pectoris ） ,there were 80 normal subjects who underwent coronary angiography and proved to not be CHD （ control group ）. All selected patients had fasting detection about hs-CRP, UA Pre- operatively. Results The levels of hs-CRP, UA in CHD （ coronary heart disease） group were significantly higher than control group （ P 〈 0. 01 ）. Linear correlation analysis showed the concentrations of UA were negatively correlated with hs-CRP levels in AMI group（ r = 0. 459, P 〈 0.01 ）, the concentrations of UA were positively correlated with hs-CRP levels in UAP group （ r = 0. 326, P 〈 0.01 ）, between the levels of hs- CRP and UA,there were not significant differences found between single vessel disease and two vessel disease, and so on. Conclusion High levels of serum UA and hs-CRP are independent risk factors for CHD. The levels of hs-CRP, UA are not correlated with severity of artery disease.