2型糖尿病合并下肢动脉硬化闭塞症的危险因素探讨

目的 探讨2型糖尿病患者合并下肢动脉硬化闭塞症（LEASOD）的突出危险因素.方法 选择2型糖尿病患者109例作为研究对象,以合并LEASOD的51例作为病例组,NLEASOD的患者58例为对照组.采用回顾性病例对照研究的方法,分别对病例组和对照组患者收集与LEASOD发病密切相关的影响因素.结果 单因素Logistic回归分析结果显示空腹血糖（FPG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、脂蛋白α（Lpα）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、血尿酸（BUA）,在病例组和对照组之间表现出与LEASOD发病有不同程度的正相关（P＜0.05）.在随后的多因素非条件Logistic回归分析中,FPG,LDL-C,Lpα,ApoA1,ApoB作为相关影响因素被选入（P＜0.05）.结论 ApoB,LDL-C为2型糖尿病合并LEASOD发病的突出危险因素.

The Analysis of Risk Factors Correlated with Lower Extremity Arteriosclerosis Occlusive Disease of Type 2 Diabetic Patients

Objective To investigate the prominent risk factors correlated with lower extremity arteriosclero- sis occlusive disease （ LEASOD ） of type 2 diabetes patients. Methods One hundred and nine cases of type 2 diabetes was selected as the object of study,divided in 51 cases with LEASOD as the case group,58 cases of NLEASOD patients as control group. By retrospective case-control study,cases and controls were collected respectively influence factors closely related to LEASOD group. Results Univariate Logistic regression analysis showed that fasting plasma glucose { FPG } , high density lipoprotein { HDL-C } , low density lipoprotein I LDL-C } , tipoprotein α （ Lpα ） , apolipoprotein A1 I ApoA11 , apolipoprotein B （ ApoB ） , serum uric acid i BUA I , were positive correlated with LEASOD disease in case group and control group （ P 〈 0.05 ）. In the subsequent multivariate non-conditional Logistic regression analysis, FPG, LDL-C,Lpct,ApoA1,ApoB as the related factors were elected{P 〈0.05}. Conclusion ApoB,LDL-C are prominent risk factors for LEASOD.