1126例病人血浆D-二聚体检测结果分析及临床应用

目的探讨定量检测血浆D-二聚体（DD）在弥散性血管内凝血（DIC）及静脉栓塞疾病（VTE）诊断中的临床价值。方法使用sysmexCA7000全自动凝血仪采用免疫比浊法对1126例来自不同科室的住院可疑病人和66例健康体检者进行血浆D-二聚体定量检测并统计分析。结果不同科室收治的可疑病人根据其病情D-二聚体水平升高的阳性率不同,其检测值与健康组之间比较均有不同的差异（P〈0.05）。ICU组：阳性率81%,检测值（851.8±206.6）ng/ml;普外科组：阳性率62%,检测值（433.6±131.4）ng/ml;呼吸内科：阳性率49%,检测值（279.1±92.3）ng/ml;血液内科：阳性率51%,检测值（341.7±102.5）ng/ml;急诊科：阳性率40%,检测值（258.9±91.7）ng/ml。其检测值与健康正常人相比差异有显著统计学意义（P〈0.05）。结论 D-二聚体的检测对于临床评价DIC,VTE疾病具有重要的意义。

Results analysis of 1126 patients’ D-Dimer in plasma and its clinical application

Objective: To determine quantitative detection of plasma D-Dimer and its clinical significance in DIC,VTE.Methods: D-Dimer of 1126 suspicious patients from different Departments and 66 healthy adults were quantitatively analyzed by immunity-turbidity method with Sysmex CA-7000 full-Automatic Coagulation Analyzer.Results: Different hospital departments received different suspicious patients.According to the patients’ disease,the positive rate of the rise D-dimer levels was different.There was a difference between the patients’ test value and the healthy persons’(P<0.05).①Intensive Care Unit: The positive rate was 81%.The test value was(851.8±206.6)ng/ml;② Normal Surgical Department: The positive rate was 62%.The test value was(433.6±131.4)ng/ml;③ Respiratory Diseases Department: The positive rate was 49%.The test value was(279.1±92.3)ng/ml;④ Hematological Department: The positive rate was 51%.The test value was(341.7±102.5ng/ml;⑤ Emergency Department: The positive rate was 40%.The test value was(258.9± 91.7)ng/ml.The difference in D-dimer test value was also significant between the patients and the healthy persons(P<0.05).Conclusion:The evaluation of the DIC and VTE disease has important significance in testing the plasma D-dimer level.It is closely related to the clinical medicine,which provides accurate and reliable bases for the clinical evaluation.