Use and safety of antihistamines in children |
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Authors: | K Mireille Chae & Michael D Tharp |
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Institution: | Department of Dermatology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois |
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Abstract: | ABSTRACT: Although first-generation antihistamines remain popular for the treatment of seasonal allergic rhinitis, atopic dermatitis, and urticaria in children, second- and third-generation antihistamines hold clear advantages over the first-generation agents, especially for the pediatric patient. The less frequent dosing schedule of the second- and third-generation agents makes administration easier for the parent. With less sedation and lower risk of adverse effects, the safety profile of second- and third-generation agents appears superior to that of first-generation agents. After briefly discussing the use of first-generation antihistamines, the pharmacokinetics, safety, and use of the newer antihistamines loratadine, cetirizine, and fexofenadine in the pediatric patient are reviewed. |
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Keywords: | allergic rhinitis antihistamine/antihistamines atopic dermatitis cetirizine child/children fexofenadine loratadine pediatric/pediatrics urticaria |
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