氟达拉滨联合异环磷酰胺治疗复发性惰性非霍奇金淋巴瘤临床观察

 目的 观察氟达拉滨联合异环磷酰胺治疗复发性惰性非霍奇金淋巴瘤（NHL）的临床疗效。方法 30例复发性惰性NHL患者分为两组。16例用COP方案（环磷酰胺600 mg·m-2·d-1，静脉滴注，第1、8天；长春新碱1.5 mg·m-2·d-1，静脉推注，第1、8天，泼尼松1 mg·kg-1·d-1，连续口服2周为1疗程）治疗至少3个疗程。14例用FI方案（氟达拉滨30 mg·m-2·d-1，静脉滴注，第1天至第5天；异环磷酰胺1.2 g·m-2·d-1，静脉滴注，第1天到第5天为1疗程）治疗至少3疗程。结果 16例用COP方案的患者中，CR3例，PR5例，有效率50.0 %。14例用FI方案的患者中CR6例，PR6例有效率85.7 %。两组有效率比较差异有统计学意义（P＜0.05）。两组患者治疗后的主要不良反应是骨髓抑制，FI方案发生粒细胞减少者为71.4 %，COP方案为68.7 %。结论 FI方案治疗复发惰性NHL的近期疗效较COP方案更好，患者具有较好的耐受性。

Efficacy of fludarabine in combination with ifosfamide for relapsed indolent non-Hodgkin lymphoma

Objective TO determine the efficacy of the combination of fludarabine and ifosfamide chemotherapy in patients with relapsed non-Hodgkin lymphoma(NHL). Methods 30 patients with relapsed in dolent NHL were divided into two groups. 16 cases were treated by COP regimen( Cyclophosphamide 600 mg/m2, day 1 and day 8, Vincristine 1.5 mg/m2, day 1 and day 8, prednison 1 mg/kg day 1 to 14). The theraputic cycles were 3 at lest. 14 cases were treated by FI regimen (fludarabine 30 mg/m2 days1 to 5, ifosfamide 1.2 m2 days1 to 5). The therapeutic cycles were 3 at least. Results Of the 16 patients with COP regimen, 3 achieved complete remission and 5 partial remission. The response rate was 50.0 %. Of the 14 patients with FI regimen, 6 achieved complete remission and 6 partial remisson.The response rate was 85.7 %. That was more effective than that of COP regimen. The mian side effect of two regiman was bone marrrow depressed. 71.4 % patients experienced granulocytopenia in FI re gimen and 68.7 % in COP regimen. Conclusion Both threatments were effective in recurrent indolent NHL. The FI regimen was more effective than that of COP regimen.The patients can endure the side effects.