不同剂量阿托伐他汀治疗冠心病临床疗效观察

目的观察不同剂量阿托伐他汀治疗冠心病的临床疗效性和安全性。方法 133例冠心病患者随机分为高剂量组和低剂量组,分别接受阿托伐他汀40mg/d和20mg/d,疗程6个月。观察两组血脂改变和不良反应情况。结果两组患者治疗后血清TC、TG和LDL-C水平明显降低,HDL-C明显增高,与治疗前比较差异均具有统计学意义(P<0.05);但高剂量组改变更为显著。两组在1个月时的不良反应发生率比较差异有统计学意义(P<0.05),在3、6个月时的差异均无统计学意义(P>0.05)。结论阿托伐他汀40mg/d可以明显减少心绞痛发作,降低血脂,安全性和阿托伐他汀20mg/d基本类似。

Clinical observation of different doses of atorvastatin in the treatment of coronary heart disease

Objective To observe the clinical effects and safety of different doses of atorvastatin in the treatment of coronary heart disease.Methods 133 patients with coronary artery disease were randomly divided into the high-dose group and low-dose group,were treated with atorvastatin in 40mg/d and 20mg/d for 6 months.The changes of blood lipid and the occurrence of adverse reactions in two groups were observed.Results After treatment,serum TC,TG and LDL-C levels were significantly decreased in two groups of patients,HDL-C was increased significantly,the differences were statistically significant(P<0.05).But more significant changes in the high-dose group.The incidence of adverse reactions in 1 month of the two groups had a significant difference(P<0.05),but in 3 and 6 months,the differences were not statistically significant(P>0.05).Conclusion Atorvastatin in the dose of 40mg/d can significantly reduce the attack of angina pectoris and the level of blood lipid,the medication safety is similar to the dose of 20mg/d.