COPD患者急性加重期凝血功能的异常表现

目的探讨COPD患者急性加重期凝血功能的异常。方法选择2010年1月～2012年1月在笔者所在医院治疗的急性加重期的COPD患者32例为研究对象,同时选择健康体检者25例作为对照,检测两组凝血功能指标,同时检测研究组肺功能指标。结果两组患者PT,APTT,Fbg比较,差异均有统计学意义(P<0.01或P<0.05)。研究组FEV1占预计值百分比,FEV1/FVC,PaO2,SaO2,中性粒细胞百分比治疗前后比较,差异均有统计学意义(P<0.01或P<0.05);治疗前与对照组比较,FEV1占预计值百分比,FEV1/FVC,中性粒细胞百分比差异均有统计学意义(P<0.01或P<0.05);治疗后与对照组比较,FEV1占预计值百分比,FEV1/FVC差异均有统计学意义(P<0.01)。结论 AECOPD患者处于高凝状态,抗凝治疗可以预防COPD患者肺血栓形成。

Coagulation disorders in AECOPD

Objective To discuss coagulation disorders in AECOPD.Methods From Jan 2010 to Jan 2012,32 cases with AECOPD were selected as study group.25 healthy as control group.Coagulation index of two groups were tested.Pulmonary function index of study group was detected.Results PT,APTT,Fbg of two groups had significant difference (P < 0.01 or P < 0.05).FEV 1 %,FEV 1 /FVC,PaO 2,SaO 2,NEUT in study group had significant difference between before and after treatment (P < 0.01 or P < 0.05).FEV 1 %,FEV 1 /FVC,NEUT had significant difference between two groups before treatment(P < 0.01 or P < 0.05).FEV 1 %,FEV 1 /FVC had significant difference between two groups after treatment(P < 0.01 or P < 0.05).Conclusion AECOPD shows coagulation disorders.Anticoagulation therapy can prevent pulmonary vascular thrombosis in AECOPD.