早期高负荷剂量氯吡格雷治疗急性冠脉综合征的疗效观察

目的分析早期高负荷剂量氯吡格雷治疗急性冠脉综合征的疗效。方法选择未进行冠脉介入治疗的急性冠脉综合征患者176例,随机分为观察组和对照组各88例。观察组采用早期高负荷剂量用药,对照组采用常规用药。比较两组患者用药后的近期疗效和远期疗效。结果两组患者治疗前和治疗后比较,其血小板聚集率计数差异均无统计学意义(P>0.05);两组患者治疗后其PAR计数均出现下降,与治疗前比较,差异有统计学意义(P<0.05);除心源性死亡外,观察组患者1年内的主要心血管不良事件发生率均低于对照组,差异有统计学意义(P<0.05)。结论早期高负荷剂量治疗急性冠脉综合征的疗效安全可靠。

Clinical observation in patients with acute coronary syndrome by early high loading dose of clopidogrel

Objective To analyze the clinical observation of patients with acute coronary syndrome by early high loading dose of clopidogrel.Methods 176 cases with acute coronary syndrome who without coronary intervention were randomly divided into the observation group and the control group,88 cases in each group.The observation group was treated with early high loading dose of medication,the control group was treated with routine medication.The therapeutic effect of two group patients after administration were compared.Results The two groups were compared before and after treatment,there were no significant differences of PAR count between two group(P>0.05);the PAR counts were decreased in two group patients after treatment,compared with treatment before,the difference was statistically significant(P<0.05);In addition to cardiac death,the major adverse cardiovascular events incidence rate in1 years in the observation group was lower than control group,the difference was statistically significant(P<0.05).Conclusion Early high loading dose in the treatment of acute coronary syndrome safety and reliable.